Document Type: Research article
Young Researcher and Elite Club, Majlesi Branch, Islamic Azad University, Isfahan, Iran
Department of Chemistry, Majlesi Branch, Islamic Azad University, Isfahan, Iran
Department of Chemical Engineering, Laboratory of Nanotechnology, Quchan University of Advanced Technology, Quchan, Iran.
A multiwall carbon nanotubes-modified carbon paste electrode (MWCNTs/MCPE) was
fabricated and used to study the electrooxidation of penicillamine (PA) by electrochemical
methods in the presence of methyldopa (MDOP) as a homogeneous mediator. The
electrochemical oxidation of PA on the new sensor has been carefully studied. The kinetic
parameters such as electron transfer coefficient, α, and catalytic reaction rate constant, K/
h, were also determined using electrochemical approaches. The electrocatalytic oxidation peak current
of PA showed a linear dependent on the PA concentrations and linear calibration curves were
obtained in the ranges of 0.2-250.0 μM of PA concentration with square wave voltammetry
(SWV) method. The detection limit (3σ) was determined as 0.1 μM. This sensor was also
examined as a fast, selective, simple and precise new sensor for voltammetric determination of
PA in real samples such as drug and urine.