Zamanian Azodi, M., Rezaei Tavirani, M., Arefi Oskouie, A., Hamdieh, M., Derakhshan, M., Ahmadzadeh, A., Zayeri, F., Nejadi, N., Rezaei Tavirani, M., Mansouri, V., Rostami Nejad, M., Vafaee, R. (2017). Fluoxetine Regulates Ig Kappa Chain C Region Expression Levels in the Serum of Obsessive-Compulsive Disorder Patients: A proteomic Approach. Iranian Journal of Pharmaceutical Research, 16(3), 1264-1271. doi: 10.22037/ijpr.2017.2083
Mona Zamanian Azodi; Mostafa Rezaei Tavirani; Afsaneh Arefi Oskouie; Mostafa Hamdieh; Mohammad Kamran Derakhshan; Alireza Ahmadzadeh; Farid Zayeri; Naser Nejadi; Majid Rezaei Tavirani; Vahid Mansouri; Mohammad Rostami Nejad; Reza Vafaee. "Fluoxetine Regulates Ig Kappa Chain C Region Expression Levels in the Serum of Obsessive-Compulsive Disorder Patients: A proteomic Approach". Iranian Journal of Pharmaceutical Research, 16, 3, 2017, 1264-1271. doi: 10.22037/ijpr.2017.2083
Zamanian Azodi, M., Rezaei Tavirani, M., Arefi Oskouie, A., Hamdieh, M., Derakhshan, M., Ahmadzadeh, A., Zayeri, F., Nejadi, N., Rezaei Tavirani, M., Mansouri, V., Rostami Nejad, M., Vafaee, R. (2017). 'Fluoxetine Regulates Ig Kappa Chain C Region Expression Levels in the Serum of Obsessive-Compulsive Disorder Patients: A proteomic Approach', Iranian Journal of Pharmaceutical Research, 16(3), pp. 1264-1271. doi: 10.22037/ijpr.2017.2083
Zamanian Azodi, M., Rezaei Tavirani, M., Arefi Oskouie, A., Hamdieh, M., Derakhshan, M., Ahmadzadeh, A., Zayeri, F., Nejadi, N., Rezaei Tavirani, M., Mansouri, V., Rostami Nejad, M., Vafaee, R. Fluoxetine Regulates Ig Kappa Chain C Region Expression Levels in the Serum of Obsessive-Compulsive Disorder Patients: A proteomic Approach. Iranian Journal of Pharmaceutical Research, 2017; 16(3): 1264-1271. doi: 10.22037/ijpr.2017.2083
Fluoxetine Regulates Ig Kappa Chain C Region Expression Levels in the Serum of Obsessive-Compulsive Disorder Patients: A proteomic Approach
1Proteomics Research Center, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran
2Psychosomatic Department, Taleghani Hospital, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
3Psychosomatic Department, Taleghani Hospital, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran. cFaculty of Medicine, Iran University of Medical Sciences, Tehran, Iran
4Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran
5Physiotherapy Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran .
6Research Institute for Gastroenterology and Liver Diseases, Gastroenterology and Liver Diseases Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Abstract
Obsessive-Compulsive Disorder (OCD) is one of the most common mental conditions. Proteome profiling may help identifying important proteins and finally shed lights to complexity of OCD underlying mechanisms. Here, by the application gel-based proteomic approach the proteome profile of patients with washing subtype of OCD before and after treatment with Fluoxetine (positive responders) are compared to healthy matched controls. However, only one of the differentially expressed proteins is examined and introduced in this paper. Proteomic analysis was by the application of two-dimensional polyacrylamide gel electrophoresis (2-D PAGE), combined with (MALDI-TOF-TOF MS)-based. Furthermore, Cytoscape Plug-in, CluePedia, conducted network analysis and biological annotation. The proteome comparison between groups identified protein with the significant expression changes (p
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