• Home
  • Browse
    • Current Issue
    • By Issue
    • By Author
    • By Subject
    • Author Index
    • Keyword Index
  • Journal Info
    • About Journal
    • Aims and Scope
    • Editorial Board
    • Publication Ethics
    • Indexing and Abstracting
    • Related Links
    • FAQ
    • Peer Review Process
    • News
  • Guide for Authors
  • Submit Manuscript
  • Reviewers
  • Contact Us
 
  • Login
  • Register
Home Articles List Article Information
  • Save Records
  • |
  • Printable Version
  • |
  • Recommend
  • |
  • How to cite Export to
    RIS EndNote BibTeX APA MLA Harvard Vancouver
  • |
  • Share Share
    CiteULike Mendeley Facebook Google LinkedIn Twitter
Iranian Journal of Pharmaceutical Research
arrow Articles in Press
arrow Current Issue
Journal Archive
Volume Volume 18 (2019)
Volume Volume 17 (2018)
Volume Volume 16 (2017)
Issue Issue 4
Issue Issue 3
Issue Issue 2
Issue Special Issue
Issue Issue 1
Volume Volume 15 (2016)
Volume Volume 14 (2015)
Volume Volume 13 (2014)
Volume Volume 12 (2013)
Volume Volume 11 (2012)
Volume Volume 10 (2011)
Volume Volume 9 (2010)
Volume Volume 8 (2009)
Volume Volume 7 (2008)
Volume Volume 6 (2007)
Volume Volume 5 (2006)
Volume Volume 4 (2005)
Volume Volume 3 (2004)
Volume Volume 2 (2003)
Volume Volume 1 (2002)
Iman, M., Saadabadi, A., Davood, A., Shafaroodi, H., Nikbakht, A., Ansari, A., Abedini, M. (2017). Docking, Synthesis and anticonvulsant activity of N-substituted isoindoline-1,3-dione. Iranian Journal of Pharmaceutical Research, 16(2), 586-595. doi: 10.22037/ijpr.2017.2045
Maryam Iman; Atefeh Saadabadi; Asghar Davood; Hamed Shafaroodi; Ali Nikbakht; Abdollah Ansari; Masood Abedini. "Docking, Synthesis and anticonvulsant activity of N-substituted isoindoline-1,3-dione". Iranian Journal of Pharmaceutical Research, 16, 2, 2017, 586-595. doi: 10.22037/ijpr.2017.2045
Iman, M., Saadabadi, A., Davood, A., Shafaroodi, H., Nikbakht, A., Ansari, A., Abedini, M. (2017). 'Docking, Synthesis and anticonvulsant activity of N-substituted isoindoline-1,3-dione', Iranian Journal of Pharmaceutical Research, 16(2), pp. 586-595. doi: 10.22037/ijpr.2017.2045
Iman, M., Saadabadi, A., Davood, A., Shafaroodi, H., Nikbakht, A., Ansari, A., Abedini, M. Docking, Synthesis and anticonvulsant activity of N-substituted isoindoline-1,3-dione. Iranian Journal of Pharmaceutical Research, 2017; 16(2): 586-595. doi: 10.22037/ijpr.2017.2045

Docking, Synthesis and anticonvulsant activity of N-substituted isoindoline-1,3-dione

Article 18, Volume 16, Issue 2, Spring 2017, Page 586-595  XML PDF (525.16 K)
Document Type: Research article
DOI: 10.22037/ijpr.2017.2045
Authors
Maryam Iman1; Atefeh Saadabadi2; Asghar Davood email 3; Hamed Shafaroodi4; Ali Nikbakht4; Abdollah Ansari4; Masood Abedini2
1Chemical Injuries Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran.
2Department of Medicinal Chemistry, Pharmaceutical Sciences Branch, Islamic Azad University, Tehran, Iran
3Department of Medicinal Chemistry, Faculty of Pharmacy, Pharmaceutical Sciences Branch, Islamic Azad University, Tehran, Iran (IAUPS).
4Department of Pharmacology, Pharmaceutical Sciences Branch, Islamic Azad University, Tehran, Iran
Abstract
A series of compounds related to ameltolide were studied for anticonvulsant potential in the subcutaneous pentylenetetrazol (sc Ptz) test in mice. These compounds were synthesized and characterized by TLC followed by IR and H1NMR. In vivo screening data acquired indicate that most of analogs have the ability to protect against PTZ-induced seizure. Phenytoin (PHT) was employed as the reference prototype antiepileptic drug. All compounds exerted their maximal effects 30 min after administration. Out of the 6 compounds, compound 2 at 40 mg/kg dose is more potent than phenytoin (reference drug) on clonic seizure. Using a model of the open pore of the Na channel, docking study was performed by AutoDock4.2 program. Docking studies has revealed that these compounds are stabilized through at least one hydrogen bond rises from ketone of phthalimide and residue Thr-87 of domain G of sodium channel.
Keywords
Anticonvulsant; Design; Isoindoline; Seizure; Synthesis
Main Subjects
Medicinal chemistry
Statistics
Article View: 1,807
PDF Download: 29,363
Home | Glossary | News | Aims and Scope | Sitemap
Top Top

Statistics

Journal Management System. Designed by sinaweb.