Technetium-99m tricarbonyl labeled a broad-spectrum quinolone as a specific imaging agent in infection diseases

Document Type: Research article

Authors

1 Science and Research branch, Islamic Azad University, P.O. Box: 14515-775, Tehran, Iran

2 Radiation Application Research School, Nuclear Science and Technology Research Institute (NSTRI), P.O.Box: 14395-836, Tehran, Iran

Abstract

Nuclear medicine imaging has been used to localize infection sites and efforts have been continued to develop modified infection specific radiopharmaceuticals. In this study gemifloxacin as a broad-spectrum quinolone has been labeled with [99mTc (CO)3 (H2O)3]+ core in order to evaluate its feasibility as an infection imaging agent for in vivo use. The stability of radioconjugate was checked in human serum at 37 °C and biodistribution was studied in mice. Labeling yield of >95% was obtained corresponding to a specific activity of 0.14 GBq/μmol. The radioconjugate showed good stability in human serum. Our main achievement was high accumulation in the infected muscle in mice (T/NT = 2.93 ± 0.3 at 1 h post injection) which may diagnostically be beneficial for differentiate sites of infection from sites of inflammation.

Keywords

Main Subjects