Abstract: A series of N-[2-(8-metoxy-2H-chromen-2-one)ethyl] piperazinyl quinolones containing a carbonyl related functional groups (oxo or oxyimino) on the ethyl spacer of coumarin and piperazin rings was synthesized and studied for their antibacterial and antifungal activities . The synthesis of compounds (6a-6l) was achieved through the versatile and efficient synthetic route that involved reaction of quinolones with appropriately α-bromo ketone or α-bromo oxime derivatives (2, 2a-c). The structures of the new compounds were confirmed by IR, Mass, 1H-NMR and 13C-NMR spectra. More good activities against gram-positive and gram-negative are shown in all compounds. Antibacterial screening of compounds 6a–l against gram-positive and gram-negative bacteria reveals that compounds 6g, 6h and 6i exhibit the most potent in-vitro antibacterial activity. The antifungal data reveals that all compounds have shown weak antifungal activity as compared to Nistatin.
Valadbeigi, E., Ghodsi, S. (2017). Synthesis and Study of Some New Quinolone Derivatives Containing a 3-acetyl Coumarin for Their Antibacterial and Antifungal Activities. Iranian Journal of Pharmaceutical Research, 16(2), 554-564. doi: 10.22037/ijpr.2017.2028
MLA
Edris Valadbeigi; Shahram Ghodsi. "Synthesis and Study of Some New Quinolone Derivatives Containing a 3-acetyl Coumarin for Their Antibacterial and Antifungal Activities". Iranian Journal of Pharmaceutical Research, 16, 2, 2017, 554-564. doi: 10.22037/ijpr.2017.2028
HARVARD
Valadbeigi, E., Ghodsi, S. (2017). 'Synthesis and Study of Some New Quinolone Derivatives Containing a 3-acetyl Coumarin for Their Antibacterial and Antifungal Activities', Iranian Journal of Pharmaceutical Research, 16(2), pp. 554-564. doi: 10.22037/ijpr.2017.2028
VANCOUVER
Valadbeigi, E., Ghodsi, S. Synthesis and Study of Some New Quinolone Derivatives Containing a 3-acetyl Coumarin for Their Antibacterial and Antifungal Activities. Iranian Journal of Pharmaceutical Research, 2017; 16(2): 554-564. doi: 10.22037/ijpr.2017.2028
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