Valadbeigi, E., Ghodsi, S. (2017). Synthesis and Study of Some New Quinolone Derivatives Containing a 3-acetyl Coumarin for Their Antibacterial and Antifungal Activities. Iranian Journal of Pharmaceutical Research, 16(2), 554-564. doi: 10.22037/ijpr.2017.2028
Edris Valadbeigi; Shahram Ghodsi. "Synthesis and Study of Some New Quinolone Derivatives Containing a 3-acetyl Coumarin for Their Antibacterial and Antifungal Activities". Iranian Journal of Pharmaceutical Research, 16, 2, 2017, 554-564. doi: 10.22037/ijpr.2017.2028
Valadbeigi, E., Ghodsi, S. (2017). 'Synthesis and Study of Some New Quinolone Derivatives Containing a 3-acetyl Coumarin for Their Antibacterial and Antifungal Activities', Iranian Journal of Pharmaceutical Research, 16(2), pp. 554-564. doi: 10.22037/ijpr.2017.2028
Valadbeigi, E., Ghodsi, S. Synthesis and Study of Some New Quinolone Derivatives Containing a 3-acetyl Coumarin for Their Antibacterial and Antifungal Activities. Iranian Journal of Pharmaceutical Research, 2017; 16(2): 554-564. doi: 10.22037/ijpr.2017.2028
Synthesis and Study of Some New Quinolone Derivatives Containing a 3-acetyl Coumarin for Their Antibacterial and Antifungal Activities
Department of Chemistry, Faculty of Sciences, Islamic Azad University, Karaj Branch, Karaj, Iran
Abstract
Abstract: A series of N-[2-(8-metoxy-2H-chromen-2-one)ethyl] piperazinyl quinolones containing a carbonyl related functional groups (oxo or oxyimino) on the ethyl spacer of coumarin and piperazin rings was synthesized and studied for their antibacterial and antifungal activities . The synthesis of compounds (6a-6l) was achieved through the versatile and efficient synthetic route that involved reaction of quinolones with appropriately α-bromo ketone or α-bromo oxime derivatives (2, 2a-c). The structures of the new compounds were confirmed by IR, Mass, 1H-NMR and 13C-NMR spectra. More good activities against gram-positive and gram-negative are shown in all compounds. Antibacterial screening of compounds 6a–l against gram-positive and gram-negative bacteria reveals that compounds 6g, 6h and 6i exhibit the most potent in-vitro antibacterial activity. The antifungal data reveals that all compounds have shown weak antifungal activity as compared to Nistatin.
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