1Women’s Health Research Center, Ghaem Health,Mashhad University of Medical Sciences, Mashhad, Iran
2Student Research Committee, Department of Midwifery, School of Nursing and Midwifery, Mashhad University of Medical Sciences, Mashhad, Iran
3Nuclear Medicine Research Center, Mashhad University of Medical Sciences, Ghaem Hospital, Mashhad, Iran
4Shahid Beheshti University of Medical Sciences
5Mashhad University of Medical Sciences
6Mashhad university of medical scienses
The aim of this research was to perform a systematic review of the efficacy of non-hormonal herbal drugs in the treatment of vaginal atrophy in postmenopausal women. Three electronic databases were systematically searched from their inception to May2015: PubMed, Cochrane Library (Cochrane Central Register of Controlled Trials) and Scopus. In this meta-analysis, vaginal maturation value was considered as the primary outcome measurement. Sample size, mean values before and after treatment and standard deviations for each outcome measurement were used for meta-analysis. Pooled difference in means calculated as the main effect size. A random-effects model was used to pool the data across studies. Heterogeneity was evaluated using Cochrane Q value. For quantiﬁcation of the heterogeneity, the I2 index was used. The meta-analysis of 10 phytoestrogen studies showed that while the standardized mean difference of vaginal maturation value increased 0.164% (95% CI: -0.746 to -.0.419), this increase was not statistically significant (P = 0.582). The meta-analysis of seven soy studies showed that while the standardized mean difference of vaginal maturation value increased 0.072% in (95% CI: -0.42 to 0.5.), this increase was not statistically significant (p = 0.777). . Overall it can be concluded that soy phytoestrogens and isoflavones can improve vaginal atrophy in postmenopausal women, although this effect was not statistically significant.