HHKV includes 4 herbal plants. In this study, we used an extract from HHKV for the rats and mice orally. All mice were divided into three groups, group 1: drinking HHKV at a dose of 2 g/kg body weight/day, group 2: drinking water, group 3: drinking Giloba at a dose of 2 mg/kg body weight/day. All rats divided into four groups, two controls receiving drinking water or receiving Giloba at a dose of 4 mg/kg body weight/day, and two tests drinking HHKV at a dose of 5 g/kg body weight/day or 10g/kg body weight/day respectively. This treatment was applied continuoslty for 14 days. After that, mice and rats were trained for conditional reflex. The results showed that extract from HHKV increase the memory of mice and rats. However, the effect of HHKV is weaker than Giloba.