1Dept. of Pharmacology and Toxicology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
2) Department of Toxicology and Pharmacology, School of Pharmacy, Hamadan University of Medical Sciences, Hamadan, Iran
3Dept. of Pharmacology and Toxicology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
4Departement Pharmacogenosy.Faculty of Pharmacy,Tehran University of medical Sciences.Tehran.Iran
Diabetes mellitus is associated with distribution of cognitive functioning. Hyperglycemia Diabetes mellitus is associated with distribution of cognitive functioning. Hyperglycemia induced oxidative stress has been proposed as a cause of memory complications of diabetes including cognitive impairment. The aim of this study was to examine total green tea extract (TGTE), a potent free radical scavenger against spatial impairment in Streptozotocin-diabetic rats. Eight weeks after diabetes induction, TGTE was administrated in drinking water 3mg/L. The learning and memory behavior was evaluated with Morris water maze task in male rats. Then for estimation of oxidative stress parameters such as lipid peroxidation (LPO), total antioxidant capacity (FRAP) and total thiol groups in blood were scarified. The total green tea extract showed improved cognitive impairment in diabetic groups but these changes weren’t significant. There was also significant increase FRAP level and total thiol groups in treated green tea groups vs. control. group. This study demonstrated the effectiveness of TGTE on spatial impairment and oxidative stress induced in diabetes mellitus.