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Iranian Journal of Pharmaceutical Research
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Karimzadeh, I., Heydari, B., Khalili, H., Shojaei, E., Ebrahimi, A. (2017). Infective endocarditis; report from a main referral teaching hospital in Iran. Iranian Journal of Pharmaceutical Research, 16(1), 390-398. doi: 10.22037/ijpr.2017.1956
Iman Karimzadeh; Behrooz Heydari; Hossein Khalili; Esfandiar Shojaei; Abdolrasool Ebrahimi. "Infective endocarditis; report from a main referral teaching hospital in Iran". Iranian Journal of Pharmaceutical Research, 16, 1, 2017, 390-398. doi: 10.22037/ijpr.2017.1956
Karimzadeh, I., Heydari, B., Khalili, H., Shojaei, E., Ebrahimi, A. (2017). 'Infective endocarditis; report from a main referral teaching hospital in Iran', Iranian Journal of Pharmaceutical Research, 16(1), pp. 390-398. doi: 10.22037/ijpr.2017.1956
Karimzadeh, I., Heydari, B., Khalili, H., Shojaei, E., Ebrahimi, A. Infective endocarditis; report from a main referral teaching hospital in Iran. Iranian Journal of Pharmaceutical Research, 2017; 16(1): 390-398. doi: 10.22037/ijpr.2017.1956

Infective endocarditis; report from a main referral teaching hospital in Iran

Article 36, Volume 16, Issue 1, Winter 2017, Page 390-398  XML PDF (390.75 K)
Document Type: Research article
DOI: 10.22037/ijpr.2017.1956
Authors
Iman Karimzadeh email 1; Behrooz Heydari2; Hossein Khalili2; Esfandiar Shojaei2; Abdolrasool Ebrahimi3
1Shiraz University of Medical Sciences
2Tehran University of Medical Sciences
3Petroleum Industry Health Organization, Asalouyeh, Iran
Abstract
Background/Objective: The aim of the present preliminary study was to assess the demographic, clinical, paraclinical, microbiological, echocardiographic, and therapeutic profile as well as in-hospital outcome of patients with infective endocarditis at a referral center for various infectious diseases in Iran.
Methods: Required demographic, clinical, plausible complications and paraclinical data were collected from patients’ medical charts. Echocardiographic findings were obtained by performing transthoracic and/or transesophageal echocardiography as clinically indicated. In addition, details of management modalities and in-hospital outcome of patients were recorded.
Results: During a 3-year period, 55 patients with definite or possible diagnosis of Infective endocarditis were admitted to the ward. Twenty one (38.2%) patients were injection drug users. Staphylococcus aureus and S. epidermidis were the most commonly isolated microorganisms. Management modalities of Infective endocarditis included antimicrobial therapy alone (48 cases) and the combination of antimicrobial therapy and surgery (7 cases).
Conclusion: The rate of negative blood culture in our cohort is high. S. aureus and S. epidermidis were the most commonly isolated microorganisms from positive blood cultures. Congestive heart failure was the most frequent infective endocarditis complication as well as indication for surgery. In-hospital mortality rate of patients was unexpectedly low.
Keywords
Infective endocarditis; clinical presentation; treatment; outcome
Main Subjects
Pharmacotherapy (Clinical Pharmacy)
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