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Iranian Journal of Pharmaceutical Research
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Hendoiee, N., Sheikhmoonesi, F., Zarghami, M., Mamashli, S., Yazdani Charati, J., Hamzehpour, R., Fattahi, S., Azadbakht, R., Kashi, Z., Ala, S., Moshayedi, M., Alinia, H. (2016). Effectiveness of Vitamin D Supplement Therapy in Chronic Stable Schizophrenic Male Patients: A Randomized Controlled Trial. Iranian Journal of Pharmaceutical Research, 15(4), 941-950. doi: 10.22037/ijpr.2016.1942
Narjes Hendoiee; Fatemeh Sheikhmoonesi; Mehran Zarghami; Shima Mamashli; Jamshid Yazdani Charati; Romina Hamzehpour; Samineh Fattahi; Rahil Azadbakht; Zahra Kashi; Shahram Ala; Mona Moshayedi; Habibollah Alinia. "Effectiveness of Vitamin D Supplement Therapy in Chronic Stable Schizophrenic Male Patients: A Randomized Controlled Trial". Iranian Journal of Pharmaceutical Research, 15, 4, 2016, 941-950. doi: 10.22037/ijpr.2016.1942
Hendoiee, N., Sheikhmoonesi, F., Zarghami, M., Mamashli, S., Yazdani Charati, J., Hamzehpour, R., Fattahi, S., Azadbakht, R., Kashi, Z., Ala, S., Moshayedi, M., Alinia, H. (2016). 'Effectiveness of Vitamin D Supplement Therapy in Chronic Stable Schizophrenic Male Patients: A Randomized Controlled Trial', Iranian Journal of Pharmaceutical Research, 15(4), pp. 941-950. doi: 10.22037/ijpr.2016.1942
Hendoiee, N., Sheikhmoonesi, F., Zarghami, M., Mamashli, S., Yazdani Charati, J., Hamzehpour, R., Fattahi, S., Azadbakht, R., Kashi, Z., Ala, S., Moshayedi, M., Alinia, H. Effectiveness of Vitamin D Supplement Therapy in Chronic Stable Schizophrenic Male Patients: A Randomized Controlled Trial. Iranian Journal of Pharmaceutical Research, 2016; 15(4): 941-950. doi: 10.22037/ijpr.2016.1942

Effectiveness of Vitamin D Supplement Therapy in Chronic Stable Schizophrenic Male Patients: A Randomized Controlled Trial

Article 35, Volume 15, Issue 4, Autumn 2016, Page 941-950  XML PDF (330.04 K)
Document Type: Research article
DOI: 10.22037/ijpr.2016.1942
Authors
Narjes Hendoiee email 1; Fatemeh Sheikhmoonesi2; Mehran Zarghami2; Shima Mamashli3; Jamshid Yazdani Charati4; Romina Hamzehpour2; Samineh Fattahi2; Rahil Azadbakht2; Zahra Kashi5; Shahram Alaorcid 6; Mona Moshayedi7; Habibollah Alinia8
1Department of Pharmacotherapy, Faculty of Pharmacy and Psychiatry and Behavioral Sciences Research Center, Addiction Institute, Mazandaran University of Medical Sciences
2Psychiatry and Behavioral Sciences Research Center, Addiction Institute and Department of Psychiatry, Mazandaran University of Medical Sciences
3Student Research Committee, Faculty of Pharmacy, Mazandaran University of Medical Sciences
4Department of Biostatistics, Health Sciences Research Center, School of Health and Psychiatry and Behavioral Sciences Research Center, Mazandaran University of Medical Sciences
5Diabetes Research Center, and Department of Endocrinology,Mazandaran University of Medical Sciences
6Department of Pharmacotherapy, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari
7Student Research Committee, Department of Pharmacotherapy, Faculty of Pharmacy, Mazandaran University of Medical Sciences
8Psychiatrist
Abstract
In this study, the aim was to determine whether adding vitamin D to the standard therapeutic regimen of schizophrenic male patients with inadequate vitamin D status could improve some aspects of the symptom burden or not. This study was an open parallel label randomized clinical trial. Eighty patients with chronic stable schizophrenia with residual symptoms and Vitamin D deficiency were recruited randomly and then received either 600000 IU Vitamin D injection once along with their antipsychotic regimen or with their antipsychotic regimen only. Serum vitamin D was measured twice: first at the baseline and again on the fourth month. Positive and Negative Syndrome Scale (PANSS) was assessed at the baseline and on the fourth month. During the study, the vitamin D serum changes in vitamin group and control group were 22.1± 19.9(95%CI =15.9-28.8) and 0.2 ± 1.7(95%CI = 0.2-0.8) (ng/ml) (p<0.001), respectively .The changes of PANSS positive subscale score (P) was-0.1±0.7 (95%CI =-0.3-0.1) and 0.00±0.8 (95%CI =-0.2-0.2) in vitamin D and control group respectively (p=0.5). The changes of PANSS negative subscale score (N) was -0.1± 0.7 (95%CI =-0.3-0.05) and -0.1±0.5 (95%CI =-0.2-0.04) in vitamin D and control group respectively (p=0.7) and there was a negative but not significant correlation between serum vitamin D level changes and PANSS negative subscale score(r= -0.04, p=0.7). We did not find a relationship between serum vitamin D level changes and the improvement of negative and positive symptoms in schizophrenic patients and more randomized clinical trials are required to confirm our findings.
Keywords
vitamin D deficiency; PANSS negative subscale score; PANSS positive subscale score Positive; Schizophrenic patients; Antipsychotic drugs
Main Subjects
Pharmacotherapy (Clinical Pharmacy)
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