• Home
  • Browse
    • Current Issue
    • By Issue
    • By Author
    • By Subject
    • Author Index
    • Keyword Index
  • Journal Info
    • About Journal
    • Aims and Scope
    • Editorial Board
    • Publication Ethics
    • Indexing and Abstracting
    • Related Links
    • FAQ
    • Peer Review Process
    • News
  • Guide for Authors
  • Submit Manuscript
  • Reviewers
  • Contact Us
 
  • Login
  • Register
Home Articles List Article Information
  • Save Records
  • |
  • Printable Version
  • |
  • Recommend
  • |
  • How to cite Export to
    RIS EndNote BibTeX APA MLA Harvard Vancouver
  • |
  • Share Share
    CiteULike Mendeley Facebook Google LinkedIn Twitter
Iranian Journal of Pharmaceutical Research
arrow Articles in Press
arrow Current Issue
Journal Archive
Volume Volume 18 (2019)
Volume Volume 17 (2018)
Volume Volume 16 (2017)
Issue Issue 4
Issue Issue 3
Issue Issue 2
Issue Special Issue
Issue Issue 1
Volume Volume 15 (2016)
Volume Volume 14 (2015)
Volume Volume 13 (2014)
Volume Volume 12 (2013)
Volume Volume 11 (2012)
Volume Volume 10 (2011)
Volume Volume 9 (2010)
Volume Volume 8 (2009)
Volume Volume 7 (2008)
Volume Volume 6 (2007)
Volume Volume 5 (2006)
Volume Volume 4 (2005)
Volume Volume 3 (2004)
Volume Volume 2 (2003)
Volume Volume 1 (2002)
Memariani, Z., Hajimahmoodi, M., Minaee, B., Khodagholi, F., Yans, A., Rahimi, R., Amin, G., Moghaddam, G., Toliyat, T., Sharifzadeh, M. (2017). Protective effect of a polyherbal traditional formula consisting of Rosa damascena Mill., Glycyrrhiza glabra L. and Nardostachys jatamansi DC. , against ethanol-induced gastric ulcer. Iranian Journal of Pharmaceutical Research, 16(2), 694-704. doi: 10.22037/ijpr.2017.1933
Zahra Memariani; Mannan Hajimahmoodi; Bagher Minaee; Fariba Khodagholi; Asal Yans; Roja Rahimi; Gholamreza Amin; Ghazaleh Moghaddam; Tayebeh Toliyat; Mohammad Sharifzadeh. "Protective effect of a polyherbal traditional formula consisting of Rosa damascena Mill., Glycyrrhiza glabra L. and Nardostachys jatamansi DC. , against ethanol-induced gastric ulcer". Iranian Journal of Pharmaceutical Research, 16, 2, 2017, 694-704. doi: 10.22037/ijpr.2017.1933
Memariani, Z., Hajimahmoodi, M., Minaee, B., Khodagholi, F., Yans, A., Rahimi, R., Amin, G., Moghaddam, G., Toliyat, T., Sharifzadeh, M. (2017). 'Protective effect of a polyherbal traditional formula consisting of Rosa damascena Mill., Glycyrrhiza glabra L. and Nardostachys jatamansi DC. , against ethanol-induced gastric ulcer', Iranian Journal of Pharmaceutical Research, 16(2), pp. 694-704. doi: 10.22037/ijpr.2017.1933
Memariani, Z., Hajimahmoodi, M., Minaee, B., Khodagholi, F., Yans, A., Rahimi, R., Amin, G., Moghaddam, G., Toliyat, T., Sharifzadeh, M. Protective effect of a polyherbal traditional formula consisting of Rosa damascena Mill., Glycyrrhiza glabra L. and Nardostachys jatamansi DC. , against ethanol-induced gastric ulcer. Iranian Journal of Pharmaceutical Research, 2017; 16(2): 694-704. doi: 10.22037/ijpr.2017.1933

Protective effect of a polyherbal traditional formula consisting of Rosa damascena Mill., Glycyrrhiza glabra L. and Nardostachys jatamansi DC. , against ethanol-induced gastric ulcer

Article 31, Volume 16, Issue 2, Spring 2017, Page 694-704  XML PDF (784.66 K)
Document Type: Research article
DOI: 10.22037/ijpr.2017.1933
Authors
Zahra Memariani1; Mannan Hajimahmoodi2; Bagher Minaee3; Fariba Khodagholiorcid 4; Asal Yans5; Roja Rahimi6; Gholamreza Amin6; Ghazaleh Moghaddam2; Tayebeh Toliyat1; Mohammad Sharifzadeh email 7
1Department of Traditional Pharmacy, Faculty of Traditional Medicine, Tehran University of Medical Sciences, Tehran, Iran
2Department of Drug and Food Control, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
3Faculty of Traditional Medicine, Tehran University of Medical Sciences, Tehran, Iran
4Shahid Beheshti University of Medical sciences, Neuroscience Research Center
5NeuroBiology Research Center, Shahid Beheshti University of Medical Sciences
6Tehran University of Medical Sciences, Faculty of Traditional Medicine, Traditional Pharmacy
7Department of Pharmacology and Toxicology, Faculty of Pharmacy, and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, Iran
Abstract
“VARD” formula consisting of Rosa damascena Mill. (Rosaceae) petal, and rhizomes of Glycyrrhiza glabra L. (Papilionaceae) and Nardostachys jatamansi DC. (Valerianaceae), has been proposed for gastric ulcer in Iranian traditional medicine. We investigated the antiulcer activity of each plant separately and in combination. The biochemical and molecular function of extracts was also evaluated. Each plant hydroalcoholic extract was standardized via determination of total phenolic and flavonoid, also phenolic compounds determination and specially glycyrrhizic acid in G. glabra by using HPLC. Rats received orally extracts of the plants (20, 40, and 80 mg/kg) and “VARD” (45 mg/kg) 1 h before ethanol administration. Two hours after receiving ethanol, animals were sacrificed; the stomach was removed for macroscopic and microscopic assessment. Also heme-oxygenase-1, glutathione, and catalase were measured in the gastric tissue of the rats pretreated by “VARD” and dose of 20 mg/kg of extracts. Among three extracts, R. damascena and G. glabra contained more total phenolic and flavonoid content respectively. Gallic acid was prominent compound in R. damascena. The extracts of R. damascena, G. glabra, and N. jatamansi significantly decreased ulcer index. ED50 values were 8.2, 31.86 and 25.08 mg/kg respectively. “VARD” significantly decreased ulcer index compared to 20 mg/kg of G. glabra (p < 0.0001) and N. jatamansi (p < 0.001). Pretreatment with “VARD” and each plant extracts (20 mg/kg) increased glutathione, catalse and heme-oxygenase-1 significantly (p < 0.05) in comparison with control group. Our findings indicate that “VARD” partly via antioxidant activity can be considered as an effective antiulcer formula.
Keywords
Antioxidant; Glycyrrhiza glabra; Heme-oxygenase-1; inflammation; Nardostachys jatamansi; Peptic ulcer; Rosa damascena
Main Subjects
toxicology and Pharmacology
Statistics
Article View: 3,663
PDF Download: 79,467
Home | Glossary | News | Aims and Scope | Sitemap
Top Top

Statistics

Journal Management System. Designed by sinaweb.