Hydro-ethanolic Extract of Portulaca oleracea Affects Beta-adrenoceptors of Guinea Pig Tracheal Smooth Muscle

Boskabady, Mohammad Hossein; Hashemzehi, Milad; Khazdair, Mohammad Reza; Askari, Vahid Reza

doi:10.22037/ijpr.2016.1913

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Iranian Journal of Pharmaceutical Research

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	Hydro-ethanolic Extract of Portulaca oleracea Affects Beta-adrenoceptors of Guinea Pig Tracheal Smooth Muscle
Article 26, Volume 15, Issue 4, Autumn 2016, Page 867-874 PDF (486.24 K)
Document Type: Research article
DOI: 10.22037/ijpr.2016.1913
Authors
Mohammad Hossein Boskabady ¹; Milad Hashemzehi²; Mohammad Reza Khazdair³; Vahid Reza Askari⁴
¹MUMS
²Neurogenic Inflammation Research Centre and Dept. of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
³Pharmaciutical Research Center and Dept. of Physiology School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
⁴Student Research Committee, Faculty of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
Abstract
The stimulatory effect of the extract of Portulaca oleracea (P. olerace) on β-adrenoceptor of tracheal smooth muscle was examined. To examine β-adrenoceptor stimulatory effect, concentration response curve to isoprenaline was obtained in pre-contracted tracheal smooth muscle in the presence of three concentrations of aqueous-ethanolic extract, propranolol and saline. Values of EC50 (the effective concentration of isoprenaline, causing 50% of maximum response) and dose ratio -1 (CR-1) were measured. This effect was tested in non-incubated tracheal smooth muscle (group 1) and incubated tissues with chlorpheniramine (group 2). Concentration-response curves to isoprenaline in the presence of two higher concentrations of the extract in group 1 and all three concentrations in group 2 showed leftward shifts compared to isoprenaline curves produced in the presence of saline in both groups. EC50 obtained in the presence of propranolol was significantly higher than that of saline in both groups of experiments (p
Keywords
Portulaca oleracea; Hydroalcoholic extract; β-adrenoceptor; Guinea pig; Trachea


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