Radioprotective effect of thymol against salivary glands dysfunction induced by ionizing radiation in rats

Document Type : Research article

Authors

1 Faculty of Pharmacy, Mazandaran University of Medical Sciences

2 Department of Radiology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran

3 Department of Oral Medicine, Faculty of Dentistry, Babol University of Medical Science, Babol, Iran

Abstract

The aim of this study was to investigate the radioprotective effect of thymol as a natural product against salivary glands dysfunction induced by ionizing radiation in rats. The rats were treated with thymol at dose of 50 mg/Kg before exposure to radiation at dose 15Gy. Salivary gland function was evaluated with radioisotope scintigraphy and then salivary gland to background counts ratio was calculated. Ionizing radiation caused significant salivary glands dysfunction at the 3th and the 70th days with reduction in radioactivity uptake in salivary glands. Ratios of salivary gland to background radioactivities were 2.0±0.05, 1.58±0.62 and 1.99±0.07 at 3th days for control, radiation, and thymol plus radiation groups, respectively. Thymol significantly protected acute and chronic salivary gland dysfunction induced by ionizing radiation in the rats. This finding may have been a promising application of thymol for the protection of salivary glands dysfunction induced by ionizing irradiation in patients exposed to radiation in head and neck cancer therapy

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Iranian Journal of Pharmaceutical Research
Volume 15, Issue 4
Autumn 2016
Pages 861-866

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