Wei, B., Yang, Z., Shi, D., yao, X., wang, M. (2016). Inhibition of monoamine oxidase by stilbenes from Rheum palmatum. Iranian Journal of Pharmaceutical Research, 15(4), 885-892. doi: 10.22037/ijpr.2016.1907
Bo Wei; Zhongduo Yang; Dan-Feng Shi; xiaojun yao; minggang wang. "Inhibition of monoamine oxidase by stilbenes from Rheum palmatum". Iranian Journal of Pharmaceutical Research, 15, 4, 2016, 885-892. doi: 10.22037/ijpr.2016.1907
Wei, B., Yang, Z., Shi, D., yao, X., wang, M. (2016). 'Inhibition of monoamine oxidase by stilbenes from Rheum palmatum', Iranian Journal of Pharmaceutical Research, 15(4), pp. 885-892. doi: 10.22037/ijpr.2016.1907
Wei, B., Yang, Z., Shi, D., yao, X., wang, M. Inhibition of monoamine oxidase by stilbenes from Rheum palmatum. Iranian Journal of Pharmaceutical Research, 2016; 15(4): 885-892. doi: 10.22037/ijpr.2016.1907
Inhibition of monoamine oxidase by stilbenes from Rheum palmatum
Seven stilbenes and one catechin were bioactivity-guidedly isolated from the rhizomes of Rheum palmatem. Their structures were identified as piceatannol(1), resveratrol(2), piceid(3), rhapontigenin(4), piceatannol-3'-O-β-D-glucopyranoside(5), rhaponticin(6), catechin(7) and desoxyrhapontigenin(8). Anti-monoamine oxidase (MAO) activities of compounds 1–8 were tested. Compounds 1 and 8 showed significant MAO inhibitory activities with IC50 values 16.4±1.5 μM and 11.5±.1.1, respectively, when the IC50 value of iproniazid as a standard was 6.5 ±0.5 μM. The selectivity of compounds 1-8 against MAO-A and MAO-B were also evaluated. The results showed that compounds 4、6、8 preferred to inhibit MAO-A rather than MAO-B with selectivity values ([IC50 of MAO-B]/ [IC50 of MAO-A]) of 4.74, 10.01 and 9.42, respectively . The preliminary structure–activity relationships (SARs) of these compounds were discussed and the molecular modeling was also performed to explore the binding mode of inhibitors at the active site of MAO-A and MAO-B.
Top