Amani, A., Kamali, H., Abbasi, S., Amini, M. (2016). Investigation of factors affecting aerodynamic performance of nebulized nanoemulsion.. Iranian Journal of Pharmaceutical Research, 15(4), 687-693. doi: 10.22037/ijpr.2016.1906
Amir Amani; Hosein Kamali; Shayan Abbasi; Mohammad Ali Amini. "Investigation of factors affecting aerodynamic performance of nebulized nanoemulsion.". Iranian Journal of Pharmaceutical Research, 15, 4, 2016, 687-693. doi: 10.22037/ijpr.2016.1906
Amani, A., Kamali, H., Abbasi, S., Amini, M. (2016). 'Investigation of factors affecting aerodynamic performance of nebulized nanoemulsion.', Iranian Journal of Pharmaceutical Research, 15(4), pp. 687-693. doi: 10.22037/ijpr.2016.1906
Amani, A., Kamali, H., Abbasi, S., Amini, M. Investigation of factors affecting aerodynamic performance of nebulized nanoemulsion.. Iranian Journal of Pharmaceutical Research, 2016; 15(4): 687-693. doi: 10.22037/ijpr.2016.1906
Investigation of factors affecting aerodynamic performance of nebulized nanoemulsion.
3Department of Biology, Faculty of Science, University of Guilan, Rasht, Iran
4Islamic Azad University
Abstract
This work aimed to prepare a nanoemulsion preparation containing budesonide and assess its aerodynamic behavior in comparison with suspension of budesonide. In-vitro aerodynamic performance of the corresponding micellar solution (ie. nanoemulsion preparation without oil) was investigated too. Nanoemulsions of almond oil containing budesonide, as a hydrophobic model drug molecule, were prepared and optimized. Then, the effect of variation of surfactant/co-surfactant concentration on the aerodynamic properties of the nebulized aerosol was studied. The results indicated that the most physically stable formulation makes the smallest aerodynamic size. The concentration of co-surfactant was also shown to be critical in determination of aerodynamic size. Furthermore, the optimized sample, with 3% w/w almond oil, 20% w/w Tween 80+Span 80 and 2% w/w ethanol showed a smaller MMAD in comparison with the commercially available suspension and the micellar solution.
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