Document Type: Research article
Department of Biochemistry, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
Department of Medicine, Section of Endocrinology, Nutrition, and Diabetes, Vitamin D, Skin and Bone Research Laboratory, Boston University Medical Center, Boston, Massachusetts, United States of America
Students’ Scientific Research Center (SSRC) ,Tehran University of Medical Sciences, Tehran, Iran
Cardiovascular Surgery Department, Tehran Heart Center ,Tehran University of Medical Sciences, Tehran, Iran
Background: Coronary artery disease (CAD) is the major cause of mortality and morbidity worldwide. The aim of this study was to explore the effect of resveratrol (RES) on Canonical β-catenin/Wnt and forkhead box O (FOXO) pathways in CAD patients.
Method: We performed this study on 10 metabolic syndrome patients with three-vessel CAD and 10 sex-aged matched healthy subjects. The effects of RES on β-Catenin, manganese superoxide dismutase (MnSOD), and peroxisome proliferator-activated receptor delta (PPAR-δ) expression were evaluated in peripheral blood mononuclear cells (PBMCs) of participants.
Results: RES could increase the MnSOD expression in CAD patients (38%, p