Effects of resveratrol on crosstalk between canonical β-catenin/Wnt and FOXO pathways in coronary artery disease patients with metabolic syndrome: a case control study

Document Type: Research article


1 Department of Biochemistry, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

2 Department of Medicine, Section of Endocrinology, Nutrition, and Diabetes, Vitamin D, Skin and Bone Research Laboratory, Boston University Medical Center, Boston, Massachusetts, United States of America

3 Students’ Scientific Research Center (SSRC) ,Tehran University of Medical Sciences, Tehran, Iran

4 Cardiovascular Surgery Department, Tehran Heart Center ,Tehran University of Medical Sciences, Tehran, Iran


Background: Coronary artery disease (CAD) is the major cause of mortality and morbidity worldwide. The aim of this study was to explore the effect of resveratrol (RES) on Canonical β-catenin/Wnt and forkhead box O (FOXO) pathways in CAD patients.
Method: We performed this study on 10 metabolic syndrome patients with three-vessel CAD and 10 sex-aged matched healthy subjects. The effects of RES on β-Catenin, manganese superoxide dismutase (MnSOD), and peroxisome proliferator-activated receptor delta (PPAR-δ) expression were evaluated in peripheral blood mononuclear cells (PBMCs) of participants.
Results: RES could increase the MnSOD expression in CAD patients (38%, p