The analgesic effect of oral administration of Artemisia dracunculus in diabetic rats: a behavioral analysis using formalin test

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Abstract

Hyperalgesia is one of the major symptoms of diabetic neuropathy in some patients and could affect their life quality. Considering the antidiabetic potential of tarragon in traditional medicine, this study was conducted to evaluate the analgesic effect of oral administration of tarragon in male streptozotocin-induced diabetic rats. For this purpose, male Wistar rats (n = 43) were randomly divided into control, tarragon-treated control, salicylate-treated control, diabetic, and tarragon-treated diabetic groups. All treatments continued for one month. At the end of the experiment, nociceptive response was evaluated in both acute and chronic phases of the standard formalin test. The results showed that there was an increase in the pain scores in both phases of the test in diabetic group (P<0.05) and administration of tarragon for one month did produce a significant reduction in nociceptive scores for both phases, especially in the second phase of the formalin test (P<0.05 and P<0.01 respectively). In contrast, sodium salicylate as positive control only reduced pain scores in the second phase. It can be concluded that oral administration of tarragon for one month has a moderate analgesic effect in diabetic rats and this may be considered as a potential treatment for diabetic neuropathy.