Combined Effects of Retinoic Acid and Hydro-Alcoholic Extract of Rosa Damascena Mill on Wound in Diabetic Rats

Document Type: Research article

Authors

1 Department of Anatomical Sciences, Cellular and Molecular Research Center, Faculty of Medical Sciences, Ahvaz Jundishapur University of Medical Sciences, Iran

2 Department of Public Health, Faculty of Hygiene Sciences, Ahvaz Jundishapur University of Medical Sciences

3 Department of Physiology, Faculty of Veterinary Medicine, Shahid Chamran University, Ahvaz

4 Department of Physiology and Diabetes Research Center, Faculty of Medical Sciences, Ahvaz Jundishapur University of Medical Sciences

5 Department of Engineering Environmental Health, Faculty of Hygiene Sciences, Ahvaz Jundishapur University of Medical Sciences, Ahvaz

Abstract

Retinoic acid and Rosa damascena are compounds that have considerable effects in the cellular proliferation and synthesis of extracellular matrix. The present study was designed to assess the combined effects of retinoic acid and Rosa damascena mill on wound in diabetic rats. Seventy-two rats were used in this study. Diabetes was induced by a single intraperitoneal injection of streptozotocin (60 mg. Kg-1). Then, a full thickness wound was created on dorsal surface of all animals. After that, rats were divided, into three groups; control (normal saline), positive control (phenytoin ), and case (combined of 0.1% Tretinoein lotion and which concentration of Rosa damascena mill ).Afterward, wounds were evaluated macroscopically and microscopically on days 5, 10 and 15. Macroscopic and microscopic evaluations showed a significant improvement (p<0.05) of wounds in case group on 5th and 10th days when compared to positive control and control groups. The combination of Retinoic acid and hydro-alcholic extract of Rosa damascena mill can accelerate wound healing in diabetic rats.

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