Jalali, F., Hatami, Z. (2016). Fast electrocatalytic determination of methimazole at an activated glassy carbon electrode. Iranian Journal of Pharmaceutical Research, 15(4), 735-741. doi: 10.22037/ijpr.2016.1837
Fahimeh Jalali; Zahra Hatami. "Fast electrocatalytic determination of methimazole at an activated glassy carbon electrode". Iranian Journal of Pharmaceutical Research, 15, 4, 2016, 735-741. doi: 10.22037/ijpr.2016.1837
Jalali, F., Hatami, Z. (2016). 'Fast electrocatalytic determination of methimazole at an activated glassy carbon electrode', Iranian Journal of Pharmaceutical Research, 15(4), pp. 735-741. doi: 10.22037/ijpr.2016.1837
Jalali, F., Hatami, Z. Fast electrocatalytic determination of methimazole at an activated glassy carbon electrode. Iranian Journal of Pharmaceutical Research, 2016; 15(4): 735-741. doi: 10.22037/ijpr.2016.1837
Fast electrocatalytic determination of methimazole at an activated glassy carbon electrode
A fast and simple voltammetric method for the determination of methimazole in pharmaceutical products was reported. A glassy carbon electrode was pretreated by anodization at +1.75 V (vs. SCE) for 5 min, followed by potential cycling in the range of 0.3-1.3 V (20 cycles). The pretreated electrode showed an excellent electrocatalytic effect on the oxidation of methimazole. Compared with untreated electrode, a large decrease (~300 mV) in the oxidation peak of methimazole was observed. The oxidation peak current at the new potential (0.4 V vs. SCE) was linearly dependent on the concentration of methimazole in the range of 7.0 - 130 μM with a detection limit of 3.7 μM (S/N = 3). The method was successfully used in the determination of methimazole in thyramozol tablets. Due to the simple and fast electrode preparation, there is no need for electrode cleaning or storage.
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