Voltammmetric Determination of Captopril Using Multiwall Carbon Nanotubes Paste Electrode in the Presence of Isoproterenol as a Mediator

Document Type: Research article

Authors

1 Young Researchers Club, Branch, Majlesi Branch, Islamic Azad University, Isfahan, Iran

2 Graduate University of Advanced Technology, Kerman, Iran

3 Department of Chemistry, Majlesi Branch, Islamic Azad University, Isfahan, Iran

Abstract

The electrocatalytic oxidation of captopril (CAP) was studied by modified carbon nanotubes paste electrode in the presence of isoproterenol (ISPT) using cyclic voltammetry (CV), chronoamperometry and square wave voltammetry (SWV). Also, the values of catalytic rate constant (k), and electron transfer coefficient (α) for CAP were calculated. The mechanism of CA electrochemical behavior at the modified electrode surface was analyzed by various electrochemical methods in the presence of mediator. The prepared modified electrode showed voltammetric responses with high sensitivity for CAP, making it very suitable for the detection of CAP at trace levels. Under the optimized conditions, the peak current was linear to CAP concentration over the concentration range of 0.3 to 90 μmol L−1 using SWV. The detection limit was 0.1 μmol L−1. The proposed method was successfully applied to the determination of CAP in the urine, tablet and patient urine samples.

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Iranian Journal of Pharmaceutical Research

Volume 15, Issue 1
Winter 2016
Pages 107-117

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