Vegesna, N., H.G, S., baligowda@gmail.com, B., M, N., HANI, U. (2016). Development of pH Sensitive Nanoparticles for Intestinal Drug Delivery Using Chemically Modified Guar Gum Co-Polymer. Iranian Journal of Pharmaceutical Research, 15(1), 83-94. doi: 10.22037/ijpr.2016.1771
Naga Sravan Kumar Varma Vegesna; SHIVAKUMAR H.G; BALAMURALIDHARA baligowda@gmail.com; Navya M; UMME HANI. "Development of pH Sensitive Nanoparticles for Intestinal Drug Delivery Using Chemically Modified Guar Gum Co-Polymer". Iranian Journal of Pharmaceutical Research, 15, 1, 2016, 83-94. doi: 10.22037/ijpr.2016.1771
Vegesna, N., H.G, S., baligowda@gmail.com, B., M, N., HANI, U. (2016). 'Development of pH Sensitive Nanoparticles for Intestinal Drug Delivery Using Chemically Modified Guar Gum Co-Polymer', Iranian Journal of Pharmaceutical Research, 15(1), pp. 83-94. doi: 10.22037/ijpr.2016.1771
Vegesna, N., H.G, S., baligowda@gmail.com, B., M, N., HANI, U. Development of pH Sensitive Nanoparticles for Intestinal Drug Delivery Using Chemically Modified Guar Gum Co-Polymer. Iranian Journal of Pharmaceutical Research, 2016; 15(1): 83-94. doi: 10.22037/ijpr.2016.1771
Development of pH Sensitive Nanoparticles for Intestinal Drug Delivery Using Chemically Modified Guar Gum Co-Polymer
The aim of the research work was to chemically modify guar gum(GG) as a pH sensitive co-polymer and formulating intestinal targeting ESO nanoparticles (NPs) using the synthesized co-polymer. Poly acrylamide-grafted-guar gum (PAAm-g-GG) co-polymer was synthesized by free radical polymerization. Chemical modification of PAAm-g-GG by alkaline hydrolysis results in formation of a pH-sensitive co-polymer. The effect of GG and acryl amide (AAm) on grafting was studied. Esomeprazole magnesium (ESO) loaded pH sensitive NPs were prepared by nano-emulsification polymer crosslinking method and characterized. Sixteen formulations were prepared and the concentration of process variables was varied to obtain nanoparticles of 200-600nm. The NPs were found to be homogenous in size distribution. The encapsulation efficiency and drug loading ranged from 33.2% to 50.1% and 12.2% to 17.2% respectively. Particle size, encapsulation efficiency and drug loading increased along with co-polymer concentration. In-vitro release studies at pH 1.2 for 2 h, followed by pH 6.8 showed that environment pH significantly affected the drug release. SEM has shown that NPs are spherical with smooth surface. The pH sensitive PAAm-g-GGNPs resisted the initial release of the drug from the drug loaded NPs in acidic pH and delayed the release process to a longer period in alkaline environment.
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