Antiulcer Properties of Glycyrrhiza Glabra L. Extract on Experimental Models of Gastric Ulcer in Mice

Document Type : Research article


1 Department of Clinical Sciences, Faculty of Veterinary Medicine, Urmia University

2 Veterinary Medicine student, Faculty of Veterinary Medicine, Urmia University


Glycyrrhiza glabra L. is used in folk medicine for treatment of stomach disorders including
peptic ulcers. The hydroalcoholic extract of Glycyrrhiza glabra L. (HEGG) was evaluated for
antiulcerogenic activity and acute toxicity profile in mice. Various doses of HEGG (50-200
mg/kg) were administered orally to animals of different groups. Omeprazole and cimetidine at
doses of 30 and 100 mg/kg were used as positive controls, respectively. Stomach was opened
along the greater curvature then ulceration index was determined examining the inner lining
of stomach.
Oral administration of the extract at 1600 mg/kg did not produce toxic symptoms and
mortality in mice. 2950 mg/kg was determined as the oral LD50. The HEGG (50–200 mg/kg)
showed a significant reduction in ulcer index in HCl/Ethanol-induced ulcer. G. glabra extract
(50-150 mg/kg) showed antiulcer activity against indomethacin-induced gastric lesions dose
dependently. The extract effectively inhibited formation of gastric lesions induced by ethanol.
The extract (200 mg/kg) was more potent than omeprazole (30 mg/kg). HEGG reduced the
ulcer index in hypothermic stress induced gastric ulcers in mice and the antiulcer effect was
comparable to that of cimetidine.
The results indicated that G. glabra hydroalcoholic extract exerted an antiulcergenic effect
that could be associated with increase in gastric mucosal defensive factors.


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