Antiplasmodial Activity and Cytotoxicity of Plants Used in Traditional Medicine of Iran for the Treatment of Fever

Document Type: Research article


1 Traditional Medicine and Materia Medica Research Centre (TMRC), Shahid Beheshti University of Medical Sciences. P.O. Box 1516745811. Tehran, Iran

2 Department of Traditional Pharmacy, School of Traditional Medicine, Shahid Beheshti University of Medical Science. P.O. Box 1516745811. Tehran, Iran

3 Department of Pharmacognosy School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran


Malaria is the most serious parasitic disease and one of the oldest recorded diseases in the world. Because of the resistance of malaria parasites to current drugs, it is necessary to discover new antiplasmodial drugs. Traditional medicine is one of the important sources of new antiplasmodial drugs.
In this study, twenty methanolic extracts from different parts of sixteen medicinal plants used in traditional medicine of Iran for the treatment of “Nobeh fever” and/ or fever were screened for in vivo antiplasmodial activity against Plasmodium berghei and cytotoxic effect on Madin–Darby bovine kidney cells (MDBK).
Eleven species (55%) were found to have antiplasmodial activity. Methanolic extract from Rosa damascena Mill. reduced parasitemia by 57.7% compared to untreated control mice at intra-peritoneal (i.p.) injection doses of 10 mg/kg per day. This is the first report that mentioned in vivo antiplasmodial activity of Rosa damascena Mill.


Main Subjects