The Rate of Physicochemical Incompatibilities, Administration Errors. Factors Correlating with Nurses᾽ Errors

Document Type: Research article


1 1-Clinical Pharmacy Department, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran.2-Chronic Respiratory Disease Research Center, NRILTD, Masih Daneshvari Hospital, Shahid Beheshti Universityof Medical Sciences, Tehran, Iran.

2 Clinical Pharmacy Department, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran

3 Pharmaceutical Care Unit, Masih Daneshvari Hospital, Tehran, Iran

4 Lung Transplantation Research Center, NRITLD, Masih Daneshvari Hospital, Tehran, Iran.


Medication errors are commonly encountered in hospital setting. Intravenous medications pose particular risks because of their greater complexity and the multiple steps required in their preparation, administration and monitoring. We aimed to determine the rate of errors during preparation and administration phase of intravenous medications and the correlation of these errors with the demographics of the nurses involved in the process. One hundred patients who were receiving IV medications were monitored by a trained pharmacist. The researcher accompanied the nurses during the preparation and administration process of IV medications. Collected data were compared with the acceptable guidelines. A checklist was filled for each IV medication. Demographic data of the nurses was collected as well. A total of 460 IV medications were recorded. Inappropriate administration rate constituted a large proportion of errors in our study (35.3%). No significant or life threatening drug interaction was recorded during the study. Evaluating the impact of the nurses’ demographic characteristics on the incidence of medication errors showed that there is a direct correlation between nurses’ employment status and the rate of medication errors, while other characteristics did not show a significant impact on the rate of administration errors. Administration errors were significantly higher in temporary 1-year contract group than other groups (P- value < 0.0001). Study results show that there should be more vigilance on administration rate of IV medications to prevent negative consequences especially by clinical pharmacists. Optimizing the working conditions of the nurses may play a crucial role.


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