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Iranian Journal of Pharmaceutical Research
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Esfahanizade, M., Mohebbi, S., Dashtbozorg, B., Amidi, S., Gudarzi, A., Ayatollahi, S., Kobarfard, F. (2015). Synthesis and Antiplatelet Aggregation Activity Evaluation of some 2-Aminopyrimidine and 2-Substituted-4,6-diaminopyrimidine Derivatives. Iranian Journal of Pharmaceutical Research, 14(2), 417-424. doi: 10.22037/ijpr.2015.1705
Marjan Esfahanizade; Shohreh Mohebbi; Behnam Dashtbozorg; Salimeh Amidi; Ali Gudarzi; Seyed Abdolmajid Ayatollahi; Farzad Kobarfard. "Synthesis and Antiplatelet Aggregation Activity Evaluation of some 2-Aminopyrimidine and 2-Substituted-4,6-diaminopyrimidine Derivatives". Iranian Journal of Pharmaceutical Research, 14, 2, 2015, 417-424. doi: 10.22037/ijpr.2015.1705
Esfahanizade, M., Mohebbi, S., Dashtbozorg, B., Amidi, S., Gudarzi, A., Ayatollahi, S., Kobarfard, F. (2015). 'Synthesis and Antiplatelet Aggregation Activity Evaluation of some 2-Aminopyrimidine and 2-Substituted-4,6-diaminopyrimidine Derivatives', Iranian Journal of Pharmaceutical Research, 14(2), pp. 417-424. doi: 10.22037/ijpr.2015.1705
Esfahanizade, M., Mohebbi, S., Dashtbozorg, B., Amidi, S., Gudarzi, A., Ayatollahi, S., Kobarfard, F. Synthesis and Antiplatelet Aggregation Activity Evaluation of some 2-Aminopyrimidine and 2-Substituted-4,6-diaminopyrimidine Derivatives. Iranian Journal of Pharmaceutical Research, 2015; 14(2): 417-424. doi: 10.22037/ijpr.2015.1705

Synthesis and Antiplatelet Aggregation Activity Evaluation of some 2-Aminopyrimidine and 2-Substituted-4,6-diaminopyrimidine Derivatives

Article 8, Volume 14, Issue 2, Spring 2015, Page 417-424  XML PDF (618.28 K)
Document Type: Research article
DOI: 10.22037/ijpr.2015.1705
Authors
Marjan Esfahanizade1; Shohreh Mohebbi2; Behnam Dashtbozorg3; Salimeh Amidi3; Ali Gudarzi3; Seyed Abdolmajid Ayatollahi4; Farzad Kobarfard email orcid 5
1Department of medicinal chemistry, school of pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Central Research Laboratories, Shahid Beheshti University of Medical Sciences, Tehran, Iran
2Department of medicinal chemistry, school of pharmacy, Zanjan University of Medical Sciences, Zanjan, Iran.
3Department of medicinal chemistry, school of pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran
4Department of medicinal chemistry, school of pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran Phytochemistry research center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
5-
Abstract
A series of novel 2-aminopyrimidine and 2-Substituted-4,6-diaminopyrimidine derivatives have been synthesized and their anti platelet aggregation activities were assessed against ADP and arachidonic acid- induced platelet aggregation in human plasma using light transmission aggregometry. None of the compounds showed satisfactory activity against the aggregation induced by ADP. However, satisfactory activities were observed in both groups against the aggregation induced by arachidonic acid. Comparing the overall results obtained for aminopyrimidines I and II indicates that 2-aminopyrimidines (I) were more active than 4,6-diaminopyrimidines (II). Among the tested derivatives, compounds Ia, Ib, IB and II16 exhibited the highest anti platelet aggregation activity (36.75, 72.4, 62.5 and 80 µM). Interestingly, compounds with fluorine substituent on phenyl ring (Ib, IB) were among the most active compounds.
Keywords
2-aminopyrimidines; 2-Substituted-4; 6-diaminopyrimidines; anti platelet aggregation
Main Subjects
Medicinal chemistry
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