The Effect of Chronic Administration of Safranal on Systolic Blood Pressure in Rats

Document Type: Research article

Authors

1 Pharmaceutical Research Center, Department of Pharmacodynamy and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences

2 School of Pharmacy, Mashhad University of Medical Sciences,

3 School of Pharmacy, Mashhad University of Medical Sciences, Mashhad

4 School of Pharmacy, Mashhad University of Medical Sciences

5 Mashhad

Abstract

Safranal, the main component of Crocus sativus essential oil, exhibits different pharmacological activities. In this study, the effects of safranal, on blood pressure of normotensive and desoxycorticosterone acetate (DOCA) - salt induced hypertensive rats in chronic administration were investigated. Three doses of safranal (1, 2 and 4 mg/kg/day) and spironolactone (50 mg/kg/day) were administrated to the different groups of normotensive and hypertensive rats (at the end of 4 weeks treatment by DOCA-salt) for five weeks. Then the effects of safranal on mean systolic blood pressure (MSBP) and heart rate (HR) were evaluated using tail cuff method. The duration of effect of safranal on SBP, was also evaluated. Our results indicated that chronic administration of safranal could reduce the MSBP in DOCA salt treated rats in a dose dependent manner. Safranal did not decrease the MSBP in normotensive rats. The data also showed that antihypertensive effects of safranal did not persist. In summary our results showed that safranal exhibits antihypertensive and normalizing effect on BP in chronic administration.

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