Development of a Rapid Derivative Spectrophotometric Method for Simultaneous Determination of Acetaminophen, Diphenhydramine and Pseudoephedrine in Tablets
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Department of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutical Research Center, Tehran University of Medical Sciences, Tehran (14155-6451), Iran
A mixture of acetaminophen, diphenhydramine hydrochloride and pseudoephedrine hydrochloride is used for the symptomatic treatment of common cold. In this study, a derivative spectrophotometric method based on zero-crossing technique was proposed for simultaneous determination of acetaminophen, diphenhydramine hydrochloride and pseudoephedrine hydrochloride. Determination of these drugs was performed using the 1D value of acetaminophen at 281.5 nm, 2D value of diphenhydramine hydrochloride at 226.0 nm and 4D value of pseudoephedrine hydrochloride at 218.0 nm. The analysis method was linear over the range of 5-50, 0.25-4, and 0.5-5 μg/mL for acetaminophen, diphenhydramine hydrochloride and pseudoephedrine hydrochloride, respectively. The within-day and between-day CV and error values for all three compounds were within an acceptable range (CV
Souri, E., Rahimi, A., Shabani Ravari, N., Barazandeh Tehrani, M. (2015). Development of a Rapid Derivative Spectrophotometric Method for Simultaneous Determination of Acetaminophen, Diphenhydramine and Pseudoephedrine in Tablets. Iranian Journal of Pharmaceutical Research, 14(2), 435-442. doi: 10.22037/ijpr.2015.1655
MLA
Effat Souri; Aghil Rahimi; Nazanin Shabani Ravari; Maliheh Barazandeh Tehrani. "Development of a Rapid Derivative Spectrophotometric Method for Simultaneous Determination of Acetaminophen, Diphenhydramine and Pseudoephedrine in Tablets". Iranian Journal of Pharmaceutical Research, 14, 2, 2015, 435-442. doi: 10.22037/ijpr.2015.1655
HARVARD
Souri, E., Rahimi, A., Shabani Ravari, N., Barazandeh Tehrani, M. (2015). 'Development of a Rapid Derivative Spectrophotometric Method for Simultaneous Determination of Acetaminophen, Diphenhydramine and Pseudoephedrine in Tablets', Iranian Journal of Pharmaceutical Research, 14(2), pp. 435-442. doi: 10.22037/ijpr.2015.1655
VANCOUVER
Souri, E., Rahimi, A., Shabani Ravari, N., Barazandeh Tehrani, M. Development of a Rapid Derivative Spectrophotometric Method for Simultaneous Determination of Acetaminophen, Diphenhydramine and Pseudoephedrine in Tablets. Iranian Journal of Pharmaceutical Research, 2015; 14(2): 435-442. doi: 10.22037/ijpr.2015.1655