The Effects of Nigella Sativa Hydro-alcoholic Extract on Memory and Brain Tissues Oxidative Damage after Repeated Seizures in Rats

Document Type: Research article

Authors

1 Neurogenic Inflammation Research Center, Department of Physiology, School of Medicine, Mashhad, University of Medical Sciences, Mashhad, Iran

2 Neurocognitive Research Center, Department of Physiology, School of Medicine, Mashhad, University of Medical Sciences, Mashhad, Iran

3 Department of Biology, Faculty of Basic Sciences, Fars Science and Research Branch, Islamic Azad University, Shiraz, Iran

4 Pharmacological Research Center of Medicinal Plants, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

5 Department of Anatomy and Cell Biology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

6 Neurogenic Inflammation Research Center, Department of Physiology, School of Medicine, Mashhad, University of Medical Sciences, Mashhad, Iran

Abstract

Regarding the therapeutic properties of Nigella sativa (NS), the effects of the plant hydro – alcoholic extract on learning, memory and brain tissues oxidative damage were investigated in penthylenetetrazole (PTZ) - induced repeated seizures.
There were 4 experimental groups including: 1- control group; received saline, 2- PTZ group ; received saline and PTZ (50 mg/kg, i.p) , 3-PTZ- NS 200 and 4- PTZ- NS 400 ; received 200 and 400 mg/kg of NS extract respectively, before PTZ injection in 5 consecutive days. Seizure scores were lower in PTZ – NS 200 and 400, furthermore the seizure onset latencies were higher in these groups than PTZ group (PIt is concluded that the hydro-alcoholic extract of NS posses beneficial effects on learning and memory impairments in repeated seizures model which is accompanied by antioxidant effects in the brain.

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