Shahrokhian, S., Ghalkhani, M., Bayat, M., Ghorbani-Bidkorbeh, F. (2015). Voltammetric Behavior and Determination of Trace Amounts of Omeprazole Using an Edge-plane Pyrolytic Graphite Electrode. Iranian Journal of Pharmaceutical Research, 14(2), 465-471.
Saeed Shahrokhian; Masoumeh Ghalkhani; Maryam Bayat; Fatemeh Ghorbani-Bidkorbeh. "Voltammetric Behavior and Determination of Trace Amounts of Omeprazole Using an Edge-plane Pyrolytic Graphite Electrode". Iranian Journal of Pharmaceutical Research, 14, 2, 2015, 465-471.
Shahrokhian, S., Ghalkhani, M., Bayat, M., Ghorbani-Bidkorbeh, F. (2015). 'Voltammetric Behavior and Determination of Trace Amounts of Omeprazole Using an Edge-plane Pyrolytic Graphite Electrode', Iranian Journal of Pharmaceutical Research, 14(2), pp. 465-471.
Shahrokhian, S., Ghalkhani, M., Bayat, M., Ghorbani-Bidkorbeh, F. Voltammetric Behavior and Determination of Trace Amounts of Omeprazole Using an Edge-plane Pyrolytic Graphite Electrode. Iranian Journal of Pharmaceutical Research, 2015; 14(2): 465-471.
Voltammetric Behavior and Determination of Trace Amounts of Omeprazole Using an Edge-plane Pyrolytic Graphite Electrode
1Department of Chemistry, Sharif University of Technology, Tehran 11155-9516, Iran, Institute for Nanoscience and Technology, Sharif University of Technology, Tehran, Iran
2Department of Chemistry, Sharif University of Technology, Tehran 11155-9516, Iran, Department of Chemistry, Faculty of Science, Shahid Rajaee Teacher Training University, Lavizan, Tehran, Iran
3Department of Chemistry, Sharif University of Technology, Tehran 11155-9516, Iran
4Department of Pharmaceutics, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Abstract
The voltammetric performance of edge-plane pyrolytic graphite (EPG) electrode via adsorptive stripping voltammetry was investigated for study of the electrochemical behavior of omeprazole (OMZ) in aqueous solution. The results revealed that the oxidation of OMZ is an irreversible pH-dependent process that proceeds with the transfer of one electron and one proton in an adsorption-controlled mechanism. The determination conditions, such as the pH values of the supporting electrolyte, accumulation time and scan rate were optimized. Simplicity, high reproducibility and low detection limit (3 nM) of the electrode response as well as wide linear range (0.01 to 4.0 µM) can be stated as significant features of this electrode. The EPG electrode was successfully applied for the determination of OMZ in pharmaceutical formulations and satisfactory results were obtained.
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