The Effect of Wheat Germ Extract on Premenstrual Syndrome Symptoms

Document Type : Research article


1 Department of Midwifery, Shahid Beheshti University of Medical Sciences.International Branch, Tehran, Iran

2 faculty member of shahid beheshti university of medical sciences.

3 Department of Traditional Pharmacy. Shahid Beheshti University of Medical Sciences, Tehran, Iran

4 Department of Biostatistics, Faculty of Paramedicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran


Pre-menstrual syndrome is one of the most common disorders in women and causes impairment in work and social relationships. Several treatment modalities have been proposed, one of which is herbal medicines. Considering the properties of wheat germ, this study aimed to determine the effects of wheat germ extract on the symptoms of premenstrual syndrome.This triple blind clinical trial was conducted on 84 women working in hospitals affiliated to Hamadan University of Medical Sciences. Subjects completed daily symptom record form for two consecutive months After definitive diagnosis of premenstrual syndrome they were randomly divided into two groups of 50 people. Then, for two consecutive months, 400 mg capsules of wheat germ extract or placebo were used three times a day, from day 16 until the fifth day of the menstrual cycle. The wheat germ caused 63.56% reduction in physical symptoms and 66.30% reduction in psychological symptoms and 64.99% of the overall marks. Although the severity of symptoms decreased in both groups, this reduction was more significant in the wheat germ extract group (p <0.001). On the other hand, physical symptoms decreased only in the wheat germ extract (p <0.001) and there was no statistically significant difference in the placebo group. No complications were observed in any of the groups. It seems that using wheat germ extract reduces general, psychological and physical symptoms.


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