Document Type: Research article
School of Pharmacy, Jiangsu University, Zhenjiang, Jiangsu
Department of Pharmaceutics, School of Pharmacy, Jiangsu University, Zhenjiang 212013, P.R. China. School of Pharmacy, China Pharmaceutical University, Nanjing 210009, P.R. China.
Department of Pharmaceutics, School of Pharmacy, Jiangsu University, Zhenjiang 212013, P.R. China.
Department of Pharmaceutics, School of Pharmacy, Jiangsu University, Zhenjiang 212013, P.R. China
Pluronic/bile salt/phospholipid mixed micelles (Pluronic/BS/PS-MM) drug carrier system for solubilization hydrophobic drugs was developed. A typical hydrophobic compound, pyrene, was selected as a representative hydrophobic compound to model the hydrophobic drugs. Five Pluronics, F68, F88, F98, F108, and F127 with different PPO chain length were studied. CMC data and solubilization capacities were obtained from a pyrene solubilization method. A closed association model was used to obtain the thermodynamic parameters: Gibbs free energy (ΔG°), enthalpy, (ΔH°) and entropy (ΔS°) of micellization. The results obtained from these experiments suggest that the mixed micelles was more stable and solubilize more pyrene than single one; and the solubilization of pyrene was strong effected by the PPO block size, thus accentuating synergistic interaction mechanism in Pluronic/BS/PS-MM. The study generated an important dataset so as to compare the effect of different Pluronics on solubility capacity of Pluronic/BS/PS-MM.