Procerenone: a Fatty acid Triterpenoid from the Fruit Pericarp of Omphalocarpum procerum (Sapotaceae)

Document Type: Research article

Authors

1 Department of Organic Chemistry, Faculty of Science, TWAS Research Unit, University of Yaoundé 1, P. O. Box 812, Yaoundé, Cameroon

2 Department of Clinical Research, University of Bern, Murtenstrasse 35, CH-3010Bern, Switzerland

3 Department of Chemistry, Faculty of science, University of Dschang, P. O. Box 67, Dschang, Cameroon

4 Department of Chemistry and Biochemistry, University of Bern, Freiestrasse 3, CH-3012 Berne, Switzerland

5 Swiss Tropical and Public Health Institute, Socinstrasse 57, CH-4002 Basel, Switzerland and, University of Basel, Petersplatz 1, CH-4003 Basel, Switzerland

6 Department of Chemistry, Higher Teacher Training College, University of Yaoundé 1, P. O. Box 47, Yaoundé, Cameroon

Abstract

Phytochemical investigation of a dichloromethane-methanol (1:1) extract of the fruit pericarp of Omphalocarpum procerum which exhibited antiplasmodial activity during preliminary screening led to the isolation of the new fatty ester triterpenoid 3β-hexadecanoyloxy-28-hydroxyolean-12-en-11-one (1), together with five known compounds 2-6. The structure of the new compound as well as those of the known compounds was established by means of spectroscopic methods and by comparison with previously reported data. Compounds 1- 4 were evaluated in vitro for their cytotoxicity against L6 cell lines and antiprotozoal activities against Plasmodium falciparum, Leishmania donovani, Trypanosoma brucei rhodesiense and Trypanosoma cruzi (species responsible for human malaria, visceral leishmaniasis, African trypanosomiasis and Chagas disease, respectively). The tested compounds showed weak to moderate antiprotozoal activity and, no significant effect was detected regarding their cytotoxic potency.

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