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Gao, Z., Yin, J., Xie, X., Lin, C., Long, H., Qi, X., liangcai Wu, L. (2014). Intracellular Signaling Mechanisms Pharmacological Action of Jasminum amplexicaule Buch.-Ham. (Oleaceae) on Gastrointestinal Secretion. Iranian Journal of Pharmaceutical Research, 13(3), 959-965. doi: 10.22037/ijpr.2014.1552
Zhenghua Gao; Junqiang Yin; Xiaolin Xie; Changhu Lin; Hanwu Long; Xiang Qi; liangcai Wu liangcai Wu. "Intracellular Signaling Mechanisms Pharmacological Action of Jasminum amplexicaule Buch.-Ham. (Oleaceae) on Gastrointestinal Secretion". Iranian Journal of Pharmaceutical Research, 13, 3, 2014, 959-965. doi: 10.22037/ijpr.2014.1552
Gao, Z., Yin, J., Xie, X., Lin, C., Long, H., Qi, X., liangcai Wu, L. (2014). 'Intracellular Signaling Mechanisms Pharmacological Action of Jasminum amplexicaule Buch.-Ham. (Oleaceae) on Gastrointestinal Secretion', Iranian Journal of Pharmaceutical Research, 13(3), pp. 959-965. doi: 10.22037/ijpr.2014.1552
Gao, Z., Yin, J., Xie, X., Lin, C., Long, H., Qi, X., liangcai Wu, L. Intracellular Signaling Mechanisms Pharmacological Action of Jasminum amplexicaule Buch.-Ham. (Oleaceae) on Gastrointestinal Secretion. Iranian Journal of Pharmaceutical Research, 2014; 13(3): 959-965. doi: 10.22037/ijpr.2014.1552

Intracellular Signaling Mechanisms Pharmacological Action of Jasminum amplexicaule Buch.-Ham. (Oleaceae) on Gastrointestinal Secretion

Article 23, Volume 13, Issue 3, Summer 2014, Page 959-965  XML PDF (1.27 MB)
Document Type: Research article
DOI: 10.22037/ijpr.2014.1552
Authors
Zhenghua Gao1; Junqiang Yin1; Xiaolin Xie2; Changhu Lin2; Hanwu Long2; Xiang Qi2; liangcai Wu liangcai Wu email 3
1The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510080, China
2The Insititute of Biology, Guizhou Academy of Sciences, Guiyang 550009, China
3Huangpu Hospital of The First Affiliated Hospital，Sun Yat-sen University, Guangzhou 510700, China
Abstract
Jasminum amplexicaule Buch.-Ham. (Oleaceae) has been commonly used in the traditional medicine in dysentery, diarrhoea and bellyache in China. In the present work, the methanol extract of Jasminum amplexicaule (JME) was examined for pharmacology on human colonic epithelial cell line T84 by the short-circuit current technique. The results showed that pretreatment of T84 cells with JME produced a concentration-dependent (0-1000 g/ml. EC50 = 0.055 mg/ml) inhibition effect on adrenalin (Adr.)–induced Cl- secretion. The maximal response was observed at 200 g/ml. It has been demonstrated that JME has a direct effect on the enterocyte. Our results also demonstrated that the JME exerted inhibitory effect on gastrointestinal Cl- secretion that effected by acting on basolateral β-adrenoreceptors. These results suggest that the Chinese traditional medicine of JME can be used for the treatment of acute diarrhea and bellyache.
Keywords
Jasminum amplexicaule; T84 cell; secretion; Anti-diarrhoea
Main Subjects
Pharmacognosy
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