Determination of antibiotics consumption in Buali_Sina Pediatric Hospital, Sari 2010-2011

Document Type: Research article

Authors

1 Department of Clinical Pharmacy, Faculty of Pharmacy, Thalassemia Research Center, Mazandaran University of Medical Sciences, Sari, Iran

2 Department of Pediatrics, faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran

3 Department of Clinical Pharmacy, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran

4 Department of Pharmaceutical Care, Bouali Sina Hospital, Mazandaran University of Medical Sciences, Sari, Iran

5 Clinical Research Development Center, Booali Sina Hospital, faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran

Abstract

Aim: The increasing prevalence of antibiotic-resistant bacteria is a major health-care problem worldwide. WHO recommends DID (daily defined dose/ 100 Inhabitant /day) as a standard tool for measurement of antibiotic consumption. Since there was not any information regarding the antibiotics usage pattern in the north of Iran, the aim of this study was determine this in our centre.
Method: This cross-sectional study was performed in Bouali Sina hospital. Using the health information system (HIS) database, records of patients hospitalized during 22 Sep 2010 – 21 Sep 2011. Data of different wards including Neonatal, NICU, PICU, Pediatrics and Pediatric surgery were separately extracted and analyzed. Drug consumption data were expressed as DID. SPSS 16 software was used for statistical analysis. Independent samples t-test was used to compare the quantitative variables.
Result: A total of 4619 in-patients records during 1 year of study including 2494 patients in fall and winter and 2125 patients in spring and summer were evaluated. The most hospitalized patients were in Pediatric ward (43.9 %). The highest DID value were obtained for ceftriaxone (21.7), ampicillin (6.05) and vancomycin (4.7), while the lowest value was for gentamicin (0.01). In both cold and warm seasons, Ceftriaxone was the most frequent prescribed antibiotic.
Conclusion: The rate of antibiotics consumption especially Ceftriaxone in our setting was significantly higher than the other centers. Strategies for more justified administration of antibiotics especially broad –spectrum ones are necessary.

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