Phytochemical investigations on chemical constituents of Achillea tenuifolia Lam.

Document Type: Research article

Authors

1 Department of Pharmacognosy,School of Pharmacy,Hamadan University of Medical Sciences

2 Department of Medicinal Chemistry,School of Pharmacy,Shaheed Beheshti University of Medical Sciences

3 Department of Pharmacognosy,School of Pharmacy,Shaheed Beheshti University of Medical Sciences

Abstract

Achillea tenuifolia Lam (Asteraceae) afforded a methanolic extract from which after fractionation in solvents with different polarities two known flavones 3’, 5- dihydroxy- 4’, 6, 7- trimethoxy flavone (eupatorine, compound 3), 5- hydroxy- 3’, 4’, 6, 7- tetramethoxyflavone (compound 4), besides stearic acid (compound 1 ), lupeol (compound 2), daucosterol (β- sitosterol 3-O- β- D- glucopyranoside, compound 5), 2, 4- dihydroxy methyl benzoate (compound 6) were isolated for the first time. The structure of isolated compounds was elucidated by means of different spectroscopic methods such as UV, IR, Mass and 1H- NMR (1D and 2D) and 13C-NMR. For further confirming of structures of isolated compounds , comparison of the spectral data of them with those reported in the litratures have been done.

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