Ghannadi, A., Fattahian, K., Shokoohinia, Y., Behbahani, M., Shahnoush, A. (2014). Anti-viral evaluation of sesquiterpene coumarins from Ferula assa-foetida against HSV-1. Iranian Journal of Pharmaceutical Research, 13(2), 523-530. doi: 10.22037/ijpr.2014.1497
Alireza Ghannadi; Khadijeh Fattahian; Yalda Shokoohinia; Mandana Behbahani; Alireza Shahnoush. "Anti-viral evaluation of sesquiterpene coumarins from Ferula assa-foetida against HSV-1". Iranian Journal of Pharmaceutical Research, 13, 2, 2014, 523-530. doi: 10.22037/ijpr.2014.1497
Ghannadi, A., Fattahian, K., Shokoohinia, Y., Behbahani, M., Shahnoush, A. (2014). 'Anti-viral evaluation of sesquiterpene coumarins from Ferula assa-foetida against HSV-1', Iranian Journal of Pharmaceutical Research, 13(2), pp. 523-530. doi: 10.22037/ijpr.2014.1497
Ghannadi, A., Fattahian, K., Shokoohinia, Y., Behbahani, M., Shahnoush, A. Anti-viral evaluation of sesquiterpene coumarins from Ferula assa-foetida against HSV-1. Iranian Journal of Pharmaceutical Research, 2014; 13(2): 523-530. doi: 10.22037/ijpr.2014.1497
Anti-viral evaluation of sesquiterpene coumarins from Ferula assa-foetida against HSV-1
1Isfahan Pharmaceutical Sciences Research Center, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran
2Department of Pharmacognosy and Biotechnology, School of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, Iran
3Department of Biotechnology, Faculty of Advanced Sciences and Technologies, University of Isfahan, Isfahan, Iran
4Department of Chemistry, University of Isfahan, Isfahan, Iran
Abstract
Several complications attributed with Herpes virus related infections and the emergence of drug resistant viruses prompt scientists to search for new drugs. Several terpenoids and coumarins have shown anti HSV effects while no sesquiterpene coumarin have been previously tested for HSV treatment. Three sesquiterpene coumarins [badrakemin acetate (1), kellerin (2) and samarcandin diasteromer (3) were isolated from the gum resin of Ferula assa-foetida, a herbal medicine with antimicrobial, antiprotozoal and antiviral effects. Compounds were identified by 1D and 2D- NMR spectroscopy and comparison with literature data. A comparative evaluation of cytotoxicity and anti-viral activity showed that kellerin (2) could significantly inhibit the cytopathic effects and reduce the viral titre of the herpes virus type 1 (HSV-1) DNA viral strains KOS at concentrations of 10, 5 and 2.5 µg/mL.
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