Document Type: Research article
School of Pharmacy, ShahidBeheshtiUniversity of Medical Sciences, Tehran, I.R. Iran
School of Pharmacy, ShahidBeheshtiUniversity of Medical Sciences, Tehran, I.R. Iran.
Food and Drug Control Laboratories, Food and Drug Deputy, Iranian Ministry of Health and Medical Education, Tehran, I.R. Iran
Faroogh Life Sciences Research Laboratory, Tehran, I.R. Iran
For the first time, a multi-residue methodfor simultaneous determination of 41LC-amenable pesticides in rice, belonging to different chemical classes has been developed in Iran by LC-MS/MS. The pesticides were analyzed simultaneously in a single run using positive electrospray ionization with multiple reaction monitoring (MRM) after extraction with slightly modified QuEChERS method. The calibration curves for each analyte were linear in the concentration range 0.02–1.0μg/g with a correlation coefficient range between 0.993 and 0.999. The LOQ and LOD were0.025 μg/g and0.008μg/g respectively, for all 41 pesticides and the mean recoveries obtained for three fortiﬁcation levels (0.025, 0.08 and 0.250μg/g ) were71-119%with satisfactory precision (RSD<20%).The developed method was used to investigate the occurrence of pesticides in 30domestic and 30 imported rice samples collected from Tehran market.Fivecompounds were detected in 11domesticand 9importedpositive samples in concentration range from 0.032μg/g to 0.081μg/g and 0.028μg/g to 0.074μg/g, respectively. With the exception of prohibited pesticides, phosphmidon and TCMTB, three permitted pesticides, cinosulfuron, triadimenol and tricyclazole, found in positive rice samples were below MRLs established by Institute of Standards and Industrial Research of Iran (ISIRI).