Qiu, X., Fei, A., Xu, Z., Wang, Z., Wang, X., Hu, L., Xu, R. (2014). Evaluation of CYP2C9 activity in rats: use of tolbutamide alone and in combined with bupropion. Iranian Journal of Pharmaceutical Research, 13(2), 635-639. doi: 10.22037/ijpr.2014.1484
Xiangjun Qiu; Aili Fei; Zhisheng Xu; Zhe Wang; Xianqin Wang; Lufeng Hu; Ren-ai Xu. "Evaluation of CYP2C9 activity in rats: use of tolbutamide alone and in combined with bupropion". Iranian Journal of Pharmaceutical Research, 13, 2, 2014, 635-639. doi: 10.22037/ijpr.2014.1484
Qiu, X., Fei, A., Xu, Z., Wang, Z., Wang, X., Hu, L., Xu, R. (2014). 'Evaluation of CYP2C9 activity in rats: use of tolbutamide alone and in combined with bupropion', Iranian Journal of Pharmaceutical Research, 13(2), pp. 635-639. doi: 10.22037/ijpr.2014.1484
Qiu, X., Fei, A., Xu, Z., Wang, Z., Wang, X., Hu, L., Xu, R. Evaluation of CYP2C9 activity in rats: use of tolbutamide alone and in combined with bupropion. Iranian Journal of Pharmaceutical Research, 2014; 13(2): 635-639. doi: 10.22037/ijpr.2014.1484
Evaluation of CYP2C9 activity in rats: use of tolbutamide alone and in combined with bupropion
1Department of Pharmacology,Medical College of Henan University of Science and Technology,
2The First Affiliated Hospital of Wenzhou Medical College
3The Second Affiliated Hospital of Wenzhou Medical College
4The First Affiliated Hospital of Wenzhou Medical College, Wenzhou 325000, China.
5Analytical and Testing Center of Wenzhou Medical College, Wenzhou 325000, China.
6the first affiliated hospital of wenzhou medical hospital
Abstract
A “cocktail”of several probe drugs is often used to evaluate metabolic activity of multiple cytochrome P450 enzymes in one session. Some interactions among probe drugs can appear and may impact the rate of biotransformation of other ones. Our presented work was to aim on the influence of bupropion on rat cytochrome P450-mediated metabolism of tolbutamide. The biotransformation rates of tolbutamide administered either separately or in combined with bupropion were compared in this our study. The results revealed that bupropion had no significant effect on tolbutamide hydroxylation. Thus, due to stability in cytochrome P450 enzyme metabolic activity in the case of combining of two model probe drugs the procedure can show to no extent differential results comparing to the single-marker use.
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