Sheikholislam, Z., Soleimani, Z., Moghimi, A., Shahhosseini, S. (2013). A convenient Simple Method for Synthesis of Meta-iodobenzylguanidine (MIBG). Iranian Journal of Pharmaceutical Research, 12(4), 729-733. doi: 10.22037/ijpr.2013.1397
Zahra Sheikholislam; Zohreh Soleimani; Abolghasem Moghimi; Soraya Shahhosseini. "A convenient Simple Method for Synthesis of Meta-iodobenzylguanidine (MIBG)". Iranian Journal of Pharmaceutical Research, 12, 4, 2013, 729-733. doi: 10.22037/ijpr.2013.1397
Sheikholislam, Z., Soleimani, Z., Moghimi, A., Shahhosseini, S. (2013). 'A convenient Simple Method for Synthesis of Meta-iodobenzylguanidine (MIBG)', Iranian Journal of Pharmaceutical Research, 12(4), pp. 729-733. doi: 10.22037/ijpr.2013.1397
Sheikholislam, Z., Soleimani, Z., Moghimi, A., Shahhosseini, S. A convenient Simple Method for Synthesis of Meta-iodobenzylguanidine (MIBG). Iranian Journal of Pharmaceutical Research, 2013; 12(4): 729-733. doi: 10.22037/ijpr.2013.1397
A convenient Simple Method for Synthesis of Meta-iodobenzylguanidine (MIBG)
1Pharmaceutical Chemistry Department, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran, P O Box: 14155-6153.
2Department of Chemistry, University of Imam Hossein.
Abstract
Radioiodinated meta iodobenzylguanidine (MIBG) is one of the important radiopharmaceuticals in Nuclear Medicine. [123/131I]MIBG is used for imaging of Adrenal medulla, studying heart sympathetic nerves, treatment of pheochromacytoma and neuroblastoma. For clinical application, radioiodinated MIBG is prepared through isotopic exchange method, which includes replacement of radioactive iodine in a nucleophilic substitution reaction with cold iodine (127I). The unlabelled MIBG hemisulfate is synthesized by the procedure described by Wieland et al (1980). The availability of a more practical and cost-effective procedure for MIBG preparation encouraged us to study the MIBG synthesis methods. In this study the preparation of MIBG through different methods were evaluated and a new method, which is one step, simple and cost-effective is introduced. The method has ability to be scaled up for production of unlabelled MIBG.
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