Mobinikhaledi, A., Hamta, A., Kalhor, M., Shariatzadeh, M. (2014). Simple Synthesis and Biological Evaluation of Some Benzimidazoles Using Sodium Hexafluroaluminate, Na3AlF6, as an Efficient Catalyst. Iranian Journal of Pharmaceutical Research, 13(1), 95-101. doi: 10.22037/ijpr.2014.1386
Akbar Mobinikhaledi; Ahmad Hamta; Mehdi Kalhor; Mehdi Shariatzadeh. "Simple Synthesis and Biological Evaluation of Some Benzimidazoles Using Sodium Hexafluroaluminate, Na3AlF6, as an Efficient Catalyst". Iranian Journal of Pharmaceutical Research, 13, 1, 2014, 95-101. doi: 10.22037/ijpr.2014.1386
Mobinikhaledi, A., Hamta, A., Kalhor, M., Shariatzadeh, M. (2014). 'Simple Synthesis and Biological Evaluation of Some Benzimidazoles Using Sodium Hexafluroaluminate, Na3AlF6, as an Efficient Catalyst', Iranian Journal of Pharmaceutical Research, 13(1), pp. 95-101. doi: 10.22037/ijpr.2014.1386
Mobinikhaledi, A., Hamta, A., Kalhor, M., Shariatzadeh, M. Simple Synthesis and Biological Evaluation of Some Benzimidazoles Using Sodium Hexafluroaluminate, Na3AlF6, as an Efficient Catalyst. Iranian Journal of Pharmaceutical Research, 2014; 13(1): 95-101. doi: 10.22037/ijpr.2014.1386
Simple Synthesis and Biological Evaluation of Some Benzimidazoles Using Sodium Hexafluroaluminate, Na3AlF6, as an Efficient Catalyst
1Department of Chemistry, Faculty of Science, Arak University, Arak 38156-8-8349, Iran.
2Department of Biology, , Faculty of Science, Arak University, Arak 38156-8-8349, Iran.
3Department of Chemistry, Faculty of Science, Payam Noor University.
4Department of Biochemistry, Shiraz University, Shiraz, Iran.
Abstract
Considerable attention has been focused on the synthesis of benzimidazoles due to having a broad spectrum of biological activities such as anti-parasitic, fungicidal, anti-thelemintic and anti-inflammatory activities. As a part of our research work in this area, a series of benzimidasole derivatives (3a-n) were synthesized in good to high yields by reaction of o-phenylenediamine and different aromatic aldehydes in the presence of sodium hexafluroaluminate, Na3AlF6, as an efficient catalyst at 50 ◦C. This environmentally benign and practical method offers several advantages, such as high yields, use of available catalyst, mild reaction conditions and easy workup. The antibacterial activity of these benzimidasoles was also evaluated using Staphylococcus aureus (mm) and Escherichia coli (mm) bacterial strain. All synthesized materials were characterized using IR and NMR spectroscopy as well as microanalyses data.
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