Haj Mohammad Ebrahim Tehrani, K., Kobarfard, F., Azerang, P., Mehravar, M., Soleimani, Z., Ghavami, G., Sardari, S. (2013). Synthesis and Antimycobacterial Activity of Symmetric
Thiocarbohydrazone Derivatives against Mycobacterium bovis BCG. Iranian Journal of Pharmaceutical Research, 12(2), 331-346.
Kamaleddin Haj Mohammad Ebrahim Tehrani; Farzad Kobarfard; Parisa Azerang; Maryam Mehravar; Zohreh Soleimani; Ghazaleh Ghavami; Soroush Sardari. "Synthesis and Antimycobacterial Activity of Symmetric
Thiocarbohydrazone Derivatives against Mycobacterium bovis BCG". Iranian Journal of Pharmaceutical Research, 12, 2, 2013, 331-346.
Haj Mohammad Ebrahim Tehrani, K., Kobarfard, F., Azerang, P., Mehravar, M., Soleimani, Z., Ghavami, G., Sardari, S. (2013). 'Synthesis and Antimycobacterial Activity of Symmetric
Thiocarbohydrazone Derivatives against Mycobacterium bovis BCG', Iranian Journal of Pharmaceutical Research, 12(2), pp. 331-346.
Haj Mohammad Ebrahim Tehrani, K., Kobarfard, F., Azerang, P., Mehravar, M., Soleimani, Z., Ghavami, G., Sardari, S. Synthesis and Antimycobacterial Activity of Symmetric
Thiocarbohydrazone Derivatives against Mycobacterium bovis BCG. Iranian Journal of Pharmaceutical Research, 2013; 12(2): 331-346.
Synthesis and Antimycobacterial Activity of Symmetric
Thiocarbohydrazone Derivatives against Mycobacterium bovis BCG
1Department of Medicinal Chemistry, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
21- Department of Medicinal Chemistry, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran. 2- Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
3Drug Design and Bioinformatics Unit, Medical Biotechnology Department, Biotechnology Research Center, Tehran, Pasteur Institute, 13164, Iran.
4Drug Design and Bioinformatics Unit, Medical Biotechnology Department, Biotechnology Research Center, Tehran, Pasteur Institute, 13164
Abstract
In this work, we reported the synthesis and evaluation of antimycobacterial and antifungal activity of a series of thiocarbohydrazone derivatives which are thiacetazone congeners. The target compounds were synthesized in superior yields by reacting thiocarbohydrazide with different aromatic aldehydes and methyl ketones. Compounds 8, 19 and 25 were found to be the most potent derivatives, exhibiting acceptable activity against Mycobacterium bovis BCG compared to thiacetazone and ethambutol as reference substances. Compounds 8, 15 and 25 exhibited the highest activity against Candida albicans. The most active compounds had a completely different aromatic ring system with various electronic, steric and lipophilic natures. This is understandable in light of the fact that carbohydrazone derivatives must undergo a metabolic activation step before exerting their anti-TB activity and different SAR rules govern each one of these two processes.
Top