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Iranian Journal of Pharmaceutical Research
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Souri, E., Hatami, A., Shabani Ravari, N., Alvandifar, F., Barazandeh Tehrani, M. (2013). Validating a Stability Indicating HPLC Method for Kinetic Study of Cetirizine Degradation in Acidic and Oxidative Conditions. Iranian Journal of Pharmaceutical Research, 12(2), 287-294. doi: 10.22037/ijpr.2013.1312
Effat Souri; Ali Hatami; Nazanin Shabani Ravari; Farhad Alvandifar; Maliheh Barazandeh Tehrani. "Validating a Stability Indicating HPLC Method for Kinetic Study of Cetirizine Degradation in Acidic and Oxidative Conditions". Iranian Journal of Pharmaceutical Research, 12, 2, 2013, 287-294. doi: 10.22037/ijpr.2013.1312
Souri, E., Hatami, A., Shabani Ravari, N., Alvandifar, F., Barazandeh Tehrani, M. (2013). 'Validating a Stability Indicating HPLC Method for Kinetic Study of Cetirizine Degradation in Acidic and Oxidative Conditions', Iranian Journal of Pharmaceutical Research, 12(2), pp. 287-294. doi: 10.22037/ijpr.2013.1312
Souri, E., Hatami, A., Shabani Ravari, N., Alvandifar, F., Barazandeh Tehrani, M. Validating a Stability Indicating HPLC Method for Kinetic Study of Cetirizine Degradation in Acidic and Oxidative Conditions. Iranian Journal of Pharmaceutical Research, 2013; 12(2): 287-294. doi: 10.22037/ijpr.2013.1312

Validating a Stability Indicating HPLC Method for Kinetic Study of Cetirizine Degradation in Acidic and Oxidative Conditions

Article 5, Volume 12, Issue 2, Spring 2013, Page 287-294  XML PDF (557 K)
Document Type: Research article
DOI: 10.22037/ijpr.2013.1312
Authors
Effat Souri email ; Ali Hatami; Nazanin Shabani Ravari; Farhad Alvandifar; Maliheh Barazandeh Tehrani
Department of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Abstract
A stability indicating High-Performance Liquid Chromatography (HPLC) method was
validated and used to study the degradation of cetirizine dihydrochloride in acidic and oxidative
conditions. The separation was carried out on a Symmetry C18 column and a mixture of 50 mM
KH2PO4 and acetonitrile (60:40 v/v, pH = 3.5) was used as the mobile phase. The method was
linear over the range of 1-20 μg/mL of cetirizine dihydrochloride (r2 > 0.999) and the withinday
and between-day precision values were less than 1.5%. The results showed that cetirizine
dihydrochloride was unstable in 2 M HCl and 0.5% H2O2. The kinetics of the acidic degradation
showed a pseudo-first-order reaction in the temperature range of 70-90°C. In addition, the
kinetics of hydrogen peroxide mediated degradation was pseudo-first-order in the temperature
range of 50-80°C.
Keywords
Cetirizine; High-performance liquid chromatography (HPLC); degradation; Kinetics; Stability
Main Subjects
Medicinal chemistry
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