Lai, C., Lai, S., Zhang, F., Chan, Y. (2010). Developmental expression of tyrosine kinase b in rat vestibular nuclear neurons responding to horizontal and vertical linear accelerations. Iranian Journal of Pharmaceutical Research, Volume 3(Supplement 1), 26-26.
CH Lai; SK Lai; FX Zhang; YS Chan. "Developmental expression of tyrosine kinase b in rat vestibular nuclear neurons responding to horizontal and vertical linear accelerations". Iranian Journal of Pharmaceutical Research, Volume 3, Supplement 1, 2010, 26-26.
Lai, C., Lai, S., Zhang, F., Chan, Y. (2010). 'Developmental expression of tyrosine kinase b in rat vestibular nuclear neurons responding to horizontal and vertical linear accelerations', Iranian Journal of Pharmaceutical Research, Volume 3(Supplement 1), pp. 26-26.
Lai, C., Lai, S., Zhang, F., Chan, Y. Developmental expression of tyrosine kinase b in rat vestibular nuclear neurons responding to horizontal and vertical linear accelerations. Iranian Journal of Pharmaceutical Research, 2010; Volume 3(Supplement 1): 26-26.
Developmental expression of tyrosine kinase b in rat vestibular nuclear neurons responding to horizontal and vertical linear accelerations
Brain-derived neurotrophic factor (BDNF) is known to be crucial for the development of peripheral vestibular neurons. However, the maturation profile of the BDNF signal transducing receptor, tyrosine kinase B (TrkB) in functionally activated otolith-related vestibular nuclear neurons of postnatal rats remains unexplored. In the present study, conscious Sprague-Dawley rats (P4 to adult) were subjected to sinusoidal linear acceleration along the vertical or horizontal axis. Neuronal activation in response to otolith stimulation was defined by the expression of c-Fos in the vestibular nucleus. Labyrinthectomized controls and normal controls showed only a few sporadically scattered c-fos-expressing neurons. In P4-6 test rats, no Fos-labeled neurons were found in the vestibular nuclei and immunostaining for TrkB was weak. The intensity for TrkB in vestibular nuclear neurons increased with age. From P7 onwards, Fos/TrkB double-labeled neurons responsive to vertical stimulation or horizontal interaural stimulation were detected; from P9 those to horizontal antero-posterior stimulation were also detected. These findings indicate a temporal disparity in the processing of gravity-related spatial orientations in space during development of central otolith neurons. At P9, Fos/TrkB double-labeled neurons responsive to horizontal interaural stimulation or vertical stimulation greatly outnumber those responsive to antero-posterior stimulation. The number of double-labeled neurons increased with age, reaching 80–85% of the total Fos-labeled vestibular nuclear neurons in the adult. Our results suggest that TrkB contributes to the mechanism of maturation in central otolith neurons.
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