(1) Rassi Jr A, Rassi A and Marcondes de Rezende J. American trypanosomiasis (Chagas disease). Infect. Dis. Clin. North Am. (2012) 26: 275–91.
(2) Angheben A, Boix L, Buonfrate D, Gobbi F, Bisoffi Z, Pupella S,
G G and
Aprili G. Chagas disease and transfusion medicine: A perspective from non-endemic countries.
Blood Transfus. (2015) 13: 540–50.
(3) Desjeux P. Leishmaniasis: current situation and new perspectives. Comp. Immunol. Microbiol. Infect. Dis. (2004) 27: 305–18.
(4) Cunningham AC. Parasitic adaptive mechanisms in infection by Leishmania. Exp. Mol. Pathol. (2002) 72: 132–41.
(5) Canuto GAB, da Cruz PLR, Faccio AT, Klassen A and Tavares MFM. Neglected diseases prioritized in Brazil under the perspective of metabolomics: A review. Electrophoresis (2015) 36: 2336–47.
(6) Cançado JR. Long term evaluation of etiological treatment of Chagas disease with benznidazole. Rev. Inst. Med. Trop. Sao Paulo (2002) 44: 29–37.
(7) Coura JR and De Castro SL. A critical review on Chagas disease chemotherapy. Mem. Inst. Oswaldo Cruz (2002) 97: 3–24.
(8) Da Silva BJM, Hage AAP, Silva EO and Rodrigues APD. Medicinal plants from the Brazilian Amazonian region and their antileishmanial activity: a review. J. Integr. Med. (2018) 16: 211–22.
(9) Hernández Vázquez L, Palazon J and Navarro Ocaña A. The pentacyclic triterpenes α,β-amyrins: a review of sources and biological activities. In: Phytochemicals-A Global Perspective of Their Role in Nutrition and Health (2012) 487–502.
(10) Klein EJ, Santos KA, Palú F, Vieira MGA and da Silva EA. Use of supercritical CO2 and ultrasound-assisted extractions to obtain α/β-amyrin-rich extracts from uvaia leaves (Eugenia pyriformis Cambess.). J. Supercrit. Fluids (2018) 137: 1–8.
(11) Arasu MV, Kim DH, Kim P Il, Jung MW, Ilavenil S, Jane M, Lee KD, Al Dhabi NA and Choi KC. In-vitro antifungal, probiotic and antioxidant properties of novel Lactobacillus plantarum K46 isolated from fermented sesame leaf. Ann. Microbiol. (2014) 64: 1333–46.
(12) Reilly TP, Bellevue FH, Woster PM and Svensson CK. Comparison of the in-vitro cytotoxicity of hydroxylamine metabolites of sulfamethoxazole and dapsone. Biochem. Pharmacol. (1998) 55: 803–10.
(13) Green LC, Wagner DA, Glogowski J, Skipper PL, Wishnok JS and Tannenbaum SR. Analysis of nitrate, nitrite, and [15N] nitrate in biological fluids. Anal. Biochem. (1982) 126: 131–8.
(14) Bonatto SJR, Oliveira HHP, Nunes EA, Pequito D, Iagher F, Coelho I, Naliwaiko K, Kryczyk M, Brito GAP, Repka J, Sabóia LV, Fukujima G, Calder PC and Fernandes LC. Fish oil supplementation improves neutrophil function during cancer chemotherapy. Lipids (2012) 47: 383–9.
(15) Oryan A. Plant-derived compounds in treatment of leishmaniasis. Iran. J. Vet. Res. (2015) 16: 1–19.
(16) Hernandez-Vazquez L, Bonfill M, Moyano E, Cusido RM, Navarro Ocaña A and Palazon J. Conversion of α-amyrin into centellosides by plant cell cultures of Centella asiatica. Biotechnol. Lett. (2010) 32: 315–9.
(17) Cordeiro SZ, Simas NK, Arruda R do C de O and Sato A. Composition of epicuticular wax layer of two species of Mandevilla (Apocynoideae, Apocynaceae) from Rio de Janeiro, Brazil. Biochem. Syst. Ecol. (2011) 39: 198–202.
(18) Frankenberger L, Mora TD, de Siqueira CD, Filippin-Monteiro FB, de Moraes MH, Biavatti MW, Steindel M and Sandjo LP. UPLC-ESI-QTOF-MS2 characterisation of Cola nitida resin fractions with inhibitory effects on NO and TNF-α released by LPS-activated J774 macrophage and on Trypanosoma cruzi and Leishmania amazonensis. Phytochem. Anal. (2018) 29: 577–89.
(19) Otuki MF, Ferreira J, Lima F V, Meyre-silva C, Muller LA, Cani GS, Santos ARS, Yunes RS and Calixto JB. Antinociceptive properties of mixture of α-amyrin and β-amyrin triterpenes: evidence for participation of protein kinase C and protein kinase A pathways. J. Pharmacol. Exp. Ther. (2005) 313: 310–8.
(20) Cardoso BK, de Oliveira HLM, Melo UZ, Fernandez CMM, Campo CF de AA, Gonçalves JE, Laverde Jr A, Romagnolo MB, Linde GA and Gazim ZC. Antioxidant activity of α and β -amyrin isolated from Myrcianthes pungens leaves. Nat. Prod. Res. (2020) 34: 1777-81.
(21) Victoria FN, Lenardão EJ, Savegnago L, Perin G, Jacob RG, Alves D, Silva WP, Motta AS and Nascente PS. Essential oil of the leaves of Eugenia uniflora L: Antioxidant and antimicrobial properties. Food Chem. Toxicol. (2012) 50: 2668–74.
(22) Bhattacharya S, Biswas M and Haldar P. The triterpenoid fraction from Trichosanthes dioica root exhibits in-vitro antileishmanial effect against Leishmania donovani promastigotes. Pharmacognosy Res. (2013) 5: 109. 12
(23) Scotti MT, Scotti L, Ishiki H, Ribeiro FF, Cruz RMD, Oliveira MP and Mendonça Jr FJB. Natural products as a source for antileishmanial and antitrypanosomal agents. Comb. Chem. High Throughput Screen (2016) 19: 537–53.
(24) Monzote L, Piñón A and Setzer W. Antileishmanial potential of tropical rainforest plant extracts. Medicines (2014) 1: 32–55.
(25) Mwangi ESK, Keriko JM, Machocho AK, Wanyonyi AW, Malebo HM, Chhabra SC and Tarus PK. Antiprotozoal activity and cytotoxicity of metabolites from leaves of Teclea trichocarpa. J. Med. Plants Res. (2010) 4: 726–31.
(26) Fournet A, Angelo A, Muñoz V, Roblot F, Hocquemiller R and Cavé A. Biological and chemical studies of Pera benensis, a Bolivian plant used in folk medicine as a treatment of cutaneous leishmaniasis. J. Ethnopharmacol. (1992) 37: 159–64.
(27) Crevelin EJ, Turatti ICC, Crotti AEM, Veneziani CS, Lopes JLC, Lopes NP and Cunha WR. Identification of biologically active triterpenes and sterols present in hexane extracts from Miconia species using high-resolution gas chromatography. Biomed. Chromatogr. (2006) 20: 827–30.
(28) Gaertner M, Müller L, Roos JF, Cani G, Santos ARS, Niero R,
Calixto JB,
Yunes RA,
Delle Monache F and
Cechinel-Filho V. Analgesic triterpenes from
Sebastiania schottiana roots.
Phytomedicine (1999) 6: 41–4.
(29) Pizzolatti MG, Koga AH, Grisard EC and Steindel M. Trypanocidal activity of extracts from Brazilian Atlantic Rain Forest plant species. Phytomedicine (2002) 9: 422–6.
(30) Lima GS, Castro-Pinto DB, MacHado GC, Maciel MAM and Echevarria A. Antileishmanial activity and trypanothione reductase effects of terpenes from the Amazonian species Croton cajucara Benth (Euphorbiaceae). Phytomedicine (2015) 22: 1133–7.
(31) Walker DM, Oghumu S, Gupta G, McGwire BS, Drew ME and Satoskar AR. Mechanisms of cellular invasion by intracellular parasites. Cell. Mol. Life Sci. (2014) 71: 1245–63.
(32) de Melo KM, de Oliveira FTB, Costa Silva RA, Gomes Quinderé AL, Marinho Filho JDB, Araújo AJ, Pereira EDB, Carvalho AA, Chaves MH, Raoe VS and Santos FA. α, β-Amyrin, a pentacyclic triterpenoid from Protium heptaphyllum suppresses adipocyte differentiation accompanied by down regulation of PPARγ and C/EBPα in 3T3-L1 cells. Biomed. Pharmacother. (2019) 109: 1860–6.
(33) Da Silva Júnior WF, De Oliveira Pinheiro JG, De Menezes DLB, De Sobral E Silva NE, De Almeida PDO, Silva Lima E, da Veiga Jr VF, de Azevedo EP and de Lima AAN. Development, physicochemical characterization and in-vitro anti-inflammatory activity of solid dispersions of α,β amyrin isolated from Protium oil resin. Molecules (2017) 22: 1512-26.
(34) Maiyo F, Moodley R, and Singh M. Phytochemistry, cytotoxicity and apoptosis studies of Β-sitosterol-3-o-glucoside and Β-amyrin from Prunus africana. Afr. J. Tradit. Complement. Altern. Med. (2016) 13: 105–12.
(35) de Saldanha RR, Martins-Papa MC, Sampaio RNR and Muniz-Junqueira MI. Meglumine antimonate treatment enhances phagocytosis and TNF-α production by monocytes in human cutaneous leishmaniasis. Trans. R. Soc. Trop. Med. Hyg. (2012) 106: 596–603.
(36) Melo CM, Morais TC, Tomé AR, Brito GAC, Chaves MH, Rao VS and Santos FA. Anti-inflammatory effect of α,β-amyrin, a triterpene from Protium heptaphyllum, on cerulein-induced acute pancreatitis in mice. Inflamm. Res. (2011) 60: 673–81.
(37) Aragao GF, Pinheiro MCC, Bandeira PN, Lemos TLG and Viana GS de B. Analgesic and anti-Inflammatory activities of the isomeric mixture of alpha- and beta-amyrin from Protium heptaphyllum (Aubl.) March. J. Herb. Pharmacother. (2008) 7: 31–47.
(38) Holanda Pinto SA, Pinto LMS, Cunha GMA, Chaves MH, Santos FA and Rao VS. Anti-inflammatory effect of α, β-Amyrin, a pentacyclic triterpene from Protium heptaphyllum in rat model of acute periodontitis. Inflammopharmacology (2008) 16: 48–52.
(39) Holanda Pinto SA, Pinto LMS, Guedes MA, Cunha GMA, Chaves MH, Santos FA and Rao VS. Antinoceptive effect of triterpenoid α,β-amyrin in rats on orofacial pain induced by formalin and capsaicin. Phytomedicine (2008) 15: 630–4.