Are molecularly imprinted polymers (MIPs) beneficial in detection and determination of mycotoxins in cereal samples?

Document Type : Review Paper


1 Department of Medicinal Chemistry, School of pharmacy, Shahid Beheshti University of medical science, Tehran, Iran.

2 Department of chemistry, Faculty of Physics and Chemistry, University of Alzahra, Vanak, Tehran, Iran.

3 Department of Pharmaceutics, School of pharmacy, Shahid Beheshti University of Medical Science, Tehran, Iran.

4 Yunus Emre Vocational School of Health Services, Department of Medical Services and Techniques, Anadolu University, Eskişehir, Turkey.

5 Department of Pharmaceutics, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran.


The process of matrix clean-up and extraction of analytes has a significant influence on the detection and determination of the analyte, especially in trace amounts. Molecularly imprinted polymers (MIPs) are solid particles that can absorb specific molecules regarding the template molecule used in the synthesis process of each type of MIP. As a result, they can be used in more effective and more specific solid-phase extraction processes. On the others hand, mycotoxins are second metabolites of molds and fungus which are potentially cytotoxic and/or genotoxic even in trace amounts, and due to extensive consumption of cereals and the great concern of public health, several methods were developed and currently are in the process of development to detect and determine the presence and the amounts of mycotoxins in cereals.
This review is aimed to investigate the application and efficacy of MIPs in detecting and determination of mycotoxins in cereals.

Graphical Abstract

Are molecularly imprinted polymers (MIPs) beneficial in detection and determination of mycotoxins in cereal samples?


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