Preparation and characterization magnetic polypyrrole composite microspheres decorated with copper(II) as a sensing platform for electrochemical detection of Carbamazepine

Document Type: Research article

Authors

1 .Nanochemistry Research Laboratory, Department of Chemistry, University of Birjand, Birjand, Iran.

2 Nanochemistry Research Laboratory, Department of Chemistry, University of Birjand, Birjand, Iran.

3 Pharmaceutical Sciences Research Center, Department of Medicinal Chemistry, Faculty of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, Iran.

Abstract

With a facile solvothermal technique, Ssynthesis and application of Fe3O4@PPy–CuIIcomposite microspheres in the carbon ionic liquid matrix have been reported as highly sensitive sensors for voltammetric determination of Carbamazepine (CBZ). The morphology, crystal phase and structure of synthesized The nanocomposite structure was confirmed by routine methods such as transmission electron microscopy (TEM), scanning electron microscopy (SEM), X-ray photoelectron spectroscopy (XPS), X-ray diffraction (XRD), Fourier translation infrared spectroscopy (FT-IR), thermal gravimetric analysis (TGA), and inductively coupled plasma atomic emission spectroscopy (ICP-AES). Under the optimized conditions, differential pulse voltammetric (DPV) peak current was proportional to the CBZ concentration in the range of 0.05 to 25 μM with the detection limit (S/N=3) of 32 nM.
The storage stability of the modified electrode was also investigated which showes that the current responses remain about 95.2% of their initial values, indicating the appreciable storage stability of this sensor.
The proposed electrode displayed excellent repeatability and long-term stability and it was satisfactorily used for determination of CBZ in real samples (urine, and serum samples) with high recovery.

Graphical Abstract

Preparation and characterization magnetic polypyrrole composite microspheres decorated with copper(II) as a sensing platform for electrochemical detection of Carbamazepine

Keywords