Fabrication and In-vitro Evaluation of Buccal Mucoadhesive Tablet of Meloxicam

Document Type: Research article

Authors

1 Department of Pharmaceutics, Faculty of Pharmacy, Islamic Azad University, Tehran, Iran.

2 Department of Pharmaceutics and Pharmaceutical Nanotechnology, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

3 Department of Pharmacy and Pharmaceutical Sciences, Faculty of Pharmacy, Islamic Azad University, Tehran, Iran.

4 Student Research Committee, Department of Pharmaceutics and Pharmaceutical Nanotechnology, School of Pharmacy Shahid Beheshti University of Medical Sciences, Tehran, Iran.

5 Department of Pharmaceutical Nanotechnology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.

6 Nanotechnology Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.

Abstract

In this study, buccal mucoadhesive tablets of meloxicam were formulated for drug delivery as an alternative route. Direct compression method was applied for the preparation of tablets. Also, different polymers, including hydroxypropyl methyl cellulose (HPMC) 1000, 4000, and 10000, as well as carbopol 934p and carbopol 971p were used as the mucoadhesive polymer and retardant polymer. Thirteen formulations were investigated with various concentrations of polymers. The physicochemical characteristics, in-vitro drug release, swelling index, and taste modification of tablets were evaluated. Also, Carr’s index and Hausner ratio were studied. In addition, zero-order, first-order, and Higuchi kinetics were investigated and the results showed that the highest correlation coefficient (R2) is related to zero-order kinetic for formulations B2 and B3. Furthermore, the highest R2 is related to Higuchi kinetic for formulation C3. Formulation B2 showed the maximum release of 99% in 12 h. The results demonstrated that Formulation B2 can be considered as a proper buccal mucoadhesive tablet of meloxicam with desired property.

Graphical Abstract

Fabrication and In-vitro Evaluation of Buccal Mucoadhesive Tablet of Meloxicam

Keywords