Approaches for the Treatment of SARS-CoV-2 Infection: A Pharmacologic View and Literature Review

Document Type: Review Paper

Authors

1 Biosun Pharmed Factory, Barkat Pharmaceutical Group, Tehran, Iran.

2 Department of Toxicology and Pharmacology, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

3 Department of Clinical Pharmacy, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Abstract

The emergence of a novel Coronavirus disease (COVID-19) inducing acute respiratory distress syndrome (ARDS) was identified in Hubei province of China in December 2019 and rapidly spread worldwide as pandemic and became a public health concern. COVID-19 disease is caused by a new virus known as SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2), which has recently offered many challenges and efforts to identify effective drugs for its prevention and treatment. Currently, there is no proven effective approach and medication against this virus. Quickly expanding clinical trials and studies on Coronavirus disease 2019 increase our knowledge regarding SARS-CoV-2 virus and introduce several potential drugs targeting virus moiety or host cell elements. Overall, 3 stages were suggested for SARS-CoV-2 infection according to the disease severity, clinical manifestations, and treatment outcomes, including mild, moderate, and severe. This review aimed to classify and summarize several medications and potential therapies according to the disease 3 stages; however, it is worth noting that no medication and therapy has been effective so far.
The emergence of a novel Coronavirus disease (COVID-19) inducing acute respiratory
distress syndrome (ARDS) was identified in Hubei province of China in December 2019 and
rapidly spread worldwide as pandemic and became a public health concern. COVID-19 disease is
caused by a new virus known as SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus
2), which has recently offered many challenges and efforts to identify effective drugs for its
prevention and treatment. Currently, there is no proven effective approach and medication against
this virus. Quickly expanding clinical trials and studies on Coronavirus disease 2019 increase
our knowledge regarding SARS-CoV-2 virus and introduce several potential drugs targeting
virus moiety or host cell elements. Overall, 3 stages were suggested for SARS-CoV-2 infection
according to the disease severity, clinical manifestations, and treatment outcomes, including
mild, moderate, and severe. This review aimed to classify and summarize several medications
and potential therapies according to the disease 3 stages; however, it is worth noting that no
medication and therapy has been effective so far.

Graphical Abstract

Approaches for the Treatment of SARS-CoV-2 Infection: A Pharmacologic View and Literature Review

Keywords