Investigating the effects of ibuprofen on the gene expression profile in Hippocampus of mice model of Alzheimer’s disease through bioinformatics analysis

Document Type: Research article

Authors

1 Proteomics Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

2 Proteomics Research Center, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

3 Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran.

10.22037/ijpr.2019.15485.13125

Abstract

Non-steroidal anti-inflammatory drugs (NSAIDs) identified effective in many diseases. One of which is neurodegenerative diseases including Alzheimer disease (AD). In this study gross alteration of gene expression in AD mice by ibuprofen treatment is investigated via Protein-protein interaction network (PPI) analysis. Expression profiling of microarray dataset GSE67306 was retrieved from GEO database and analyzed via GEO2R tool. PPI analysis was performed via Cytoscape 3.7.0. and its plug-ins including Network Analyzer, Gene MANIA, and CluePedia. Numbers of 10 central genes including Htr1a, Sstr2, Drd2, Htr1b, Penk, Pomc, Oprm1, Npy, Sst, and Chrm2 were identified as potential biomarkers. However, the role of Penk gene was highlighted. The finding indicates that ibuprofen changes gene expression level of several genes that are involved in AD.

Graphical Abstract

Investigating the effects of ibuprofen on the gene expression profile in Hippocampus of mice model of Alzheimer’s disease through bioinformatics analysis

Keywords