Fraction Bioactivity Screening of Mulberry Leaf and Two Flavonoids in Combination with Cisplatin on Human Gastric Adenocarcinoma Cells

Document Type : Research article


1 Drug Design and Bioinformatics Unit, Medical Biotechnology Department, Biotechnology Research Center, Pasteur Institute of Iran, Tehran, Iran.

2 Cell-Based Therapies Research Center, Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran.

3 Cancer Biology Research center, Tehran University of Medical Sciences (TUMS), Tehran, Iran.


The successful therapy strategy of gastric cancer is defined as devastating of the cancerous cells without exposing systematic toxicity and undesirable side effects. One strategy to overcome cancer treatment related difficulties could be combination therapy with natural products with anticancer drugs to introduce effective antitumor effects in addition to reduction of undesirable side effects. On the subject of the pointed fact, different extracts of mulberry leaf, isoquercetin and rutin as reported extracted flavonoids from M. alba in single doses as well as in combination with cisplatin against gastric cancer cell line were prescribed. This innovative treatment led to inspiration of cytotoxicity on gastric cancer in synergistic manner. The findings anticipated that these herbal products have exceptional potential for future gastric cancer therapy investigations.

Graphical Abstract

Fraction Bioactivity Screening of Mulberry Leaf and Two Flavonoids in Combination with Cisplatin on Human Gastric Adenocarcinoma Cells


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